A broad-spectrum antibiotic powder combining Tiamulin and Chlortetracycline for the treatment and control of respiratory and enteric infections in poultry, including Mycoplasma gallisepticum and bacterial enteritis.
Product Name: TACZONE
Type: Antibiotic Powder (Water Soluble)
COMPOSITION
Each 100 g contains:
- Tiamulin hydrogen fumarate USP ...... 10 g
- Chlortetracycline hydrochloride USP ...... 30 g
- Excipients ...... q.s. to 100 g
DESCRIPTION
TACZONE is a broad-spectrum antibiotic combination specifically formulated for poultry. It contains Tiamulin, a semi-synthetic diterpene antibiotic belonging to the pleuromutilin class, and Chlortetracycline, a first-generation tetracycline antibiotic [citation:6][citation:7].
Tiamulin acts by inhibiting bacterial protein synthesis at the ribosomal level, demonstrating potent activity against Mycoplasma species and Gram-positive bacteria [citation:4][citation:6]. Chlortetracycline complements this activity with its broad-spectrum action against both Gram-positive and Gram-negative bacteria, as well as some intracellular pathogens [citation:5][citation:7].
The synergistic combination of Tiamulin and Chlortetracycline has been shown to provide enhanced efficacy against Mycoplasma gallisepticum infection, a major respiratory pathogen in poultry, compared to either agent used alone [citation:4]. This combination is particularly valuable for controlling respiratory disease complexes where multiple pathogens are involved [citation:3].
INDICATIONS
TACZONE is indicated for the treatment and control of the following conditions in poultry:
- Mycoplasma infections including Mycoplasma gallisepticum (Chronic Respiratory Disease - CRD) and Mycoplasma synoviae (infectious synovitis) [citation:4]
- Bacterial respiratory infections associated with secondary bacterial invaders following viral or mycoplasmal infections
- Enteric infections caused by susceptible bacteria including E. coli and Salmonella spp.
- Control of mixed infections where both Mycoplasma and bacterial pathogens are present
- Supportive therapy for respiratory disease complexes in broilers and layers
DOSAGE & ADMINISTRATION
For oral administration via drinking water. Fresh solution should be prepared daily.
Recommended Dosage:
- Broilers and Growers: 100 g per 200-400 liters of drinking water (equivalent to 25-50 mg Tiamulin and 75-150 mg Chlortetracycline per liter) for 3-5 consecutive days [citation:3][citation:4]
- Layers and Breeders: 100 g per 250-300 liters of drinking water for 3-5 consecutive days
- Severe Infections: Treatment may be extended up to 7 days under veterinary supervision [citation:3][citation:8]
Administration Guidelines:
- Calculate total daily water consumption and prepare sufficient medicated water accordingly
- Ensure all birds have access to medicated water
- Withhold other water sources during treatment to ensure complete dosage
- Discard any remaining medicated water after 24 hours and prepare fresh solution
- For feed administration, TACZONE can be mixed into feed at a rate of 1 kg per 1000 kg of feed
WITHDRAWAL PERIOD
- Meat (Chickens): 7 days [citation:5][citation:9]
- Eggs: Not for use in laying birds producing eggs for human consumption unless local regulations permit
PRECAUTIONS & CONTRAINDICATIONS
- Do not administer concurrently with ionophore anticoccidials (e.g., salinomycin, monensin, narasin) as severe toxicity and adverse reactions may occur, including leg weakness, depression, and increased mortality [citation:3][citation:8]
- A withdrawal period of at least 5 days should be observed between TACZONE treatment and use of ionophore anticoccidials [citation:8]
- Do not use in birds with known hypersensitivity to pleuromutilins or tetracyclines
- Do not use in laying hens producing eggs for human consumption
- Operator Safety: Avoid inhalation and direct contact with skin or eyes. Use appropriate protective equipment when handling the product. Wash hands thoroughly after use.
- Environmental Precautions: Do not contaminate water sources with unused or expired product. Dispose of packaging responsibly according to local regulations.
- Store in a cool, dry place below 30°C, protected from light and moisture.
- Keep out of reach of children.
Target Species: Poultry (Broilers, Growers, Pullets)
Pack Sizes: 1 kg
PRODUCT SUMMARY
TACZONE Powder Antibiotic Each 100g contains:- Tiamulin hydrogen fumarate USP……….10g Chlortetracycline hydrochloride USP……….30g Poultry 1 Kg
FOR VETERINARY USE ONLY
