Combination antibiotic powder for poultry containing fosfomycin calcium (200 mg/g), tylosin tartrate (100 mg/g), fructose, sodium phosphate, and magnesium sulphate. Provides synergistic bactericidal activity against gram-positive, gram-negative bacteria, and Mycoplasma for treatment of respiratory and digestive tract infections.
Product Name: FOSFOZONE
Type: Oral Water-Soluble Powder - Antibiotic Combination with Electrolytes
COMPOSITION
Each 100 g contains:
- Fosfomycin Calcium BP ...... 20 g (20% w/w, 200 mg per gram)
- Tylosin Tartrate USP ...... 10 g (10% w/w, 100 mg per gram)
- Fructose USP ...... 18 g (18% w/w)
- Sodium Phosphate USP ...... 15 g (15% w/w)
- Magnesium Sulphate USP ...... 10 g (10% w/w)
DESCRIPTION
FOSFOZONE is a broad-spectrum antibiotic combination powder containing fosfomycin calcium and tylosin tartrate, supplemented with electrolytes and energy source (fructose). This synergistic formulation provides enhanced antibacterial activity against both gram-positive and gram-negative bacteria, as well as Mycoplasma species, making it an effective treatment for respiratory and digestive tract infections in poultry [citation:1][citation:2].
Fosfomycin is a natural bactericidal broad-spectrum antibiotic that acts on proliferating bacteria by inhibiting cell wall synthesis, specifically targeting the early stages of murein/peptidoglycan formation [citation:1][citation:2]. Tylosin is a macrolide antibiotic with bacteriostatic action, highly effective against Mycoplasma species and gram-positive bacteria [citation:4]. The combination of fosfomycin and tylosin exhibits synergistic action, providing comprehensive coverage for mixed infections [citation:1][citation:5].
MECHANISM OF ACTION
Fosfomycin Calcium:
- Inhibits bacterial cell wall synthesis by blocking the enzyme UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) [citation:1]
- Disrupts the formation of peptidoglycan, a critical component of the bacterial cell wall
- Exhibits concentration-dependent bactericidal activity
- Effective against both gram-positive and gram-negative bacteria, including resistant strains [citation:1]
Tylosin Tartrate:
- Inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit [citation:4]
- Interferes with peptidyl transferase activity, preventing peptide bond formation
- Exhibits primarily bacteriostatic activity with bactericidal effects at higher concentrations
- Highly effective against Mycoplasma species, gram-positive bacteria, and some gram-negative bacteria [citation:1][citation:4]
Synergistic Combination:
- Fosfomycin and tylosin exhibit a synergistic effect, broadening the antibacterial spectrum and enhancing overall efficacy [citation:1][citation:2]
- Fosfomycin's cell wall disruption may facilitate tylosin penetration into bacterial cells
- The combination is particularly effective against mixed infections involving both Mycoplasma and enteric bacteria [citation:5]
Electrolytes and Energy Source:
- Fructose: Provides an immediate energy source for recovering birds
- Sodium Phosphate and Magnesium Sulphate: Replenish electrolytes lost during diarrhea or dehydration, supporting recovery and hydration
ANTIMICROBIAL SPECTRUM
FOSFOZONE is effective against a broad range of microorganisms:
Mycoplasma:
- Mycoplasma gallisepticum - chronic respiratory disease (CRD) [citation:1][citation:4]
- Mycoplasma synoviae - infectious synovitis, respiratory disease [citation:4]
- Mycoplasma meleagridis - in turkeys
Gram-Positive Bacteria:
- Staphylococcus spp. - staphylococcosis [citation:1][citation:8]
- Streptococcus spp. - streptococcal infections
- Clostridium perfringens - necrotic enteritis [citation:4]
Gram-Negative Bacteria:
- Escherichia coli - colibacillosis [citation:1][citation:9]
- Salmonella spp. - salmonellosis, fowl typhoid, pullorum disease [citation:1]
- Pasteurella multocida - fowl cholera [citation:1]
- Haemophilus paragallinarum - infectious coryza [citation:1][citation:8]
- Klebsiella spp., Pseudomonas spp. [citation:1]
INDICATIONS
FOSFOZONE is indicated for the treatment and control of respiratory and digestive tract infections in poultry caused by fosfomycin and tylosin-sensitive bacteria [citation:1][citation:5].
Disease Conditions:
- Chronic Respiratory Disease (CRD) - mycoplasmosis caused by Mycoplasma gallisepticum [citation:1][citation:4]
- Complex Chronic Respiratory Disease (CCRD) - mixed infections involving Mycoplasma and E. coli [citation:1]
- Colibacillosis - E. coli infections causing airsacculitis, pericarditis, perihepatitis [citation:1][citation:8]
- Salmonellosis - fowl typhoid, pullorum disease, paratyphoid infections [citation:1][citation:8]
- Fowl Cholera - Pasteurella multocida infection [citation:1]
- Infectious Coryza - Haemophilus paragallinarum infection [citation:1][citation:8]
- Ornithobacterium rhinotracheale (ORT) infection [citation:8]
- Infectious Sinusitis and Synovitis - in turkeys [citation:4][citation:8]
- Necrotic Enteritis - Clostridium perfringens infection [citation:4]
- Secondary bacterial infections associated with viral diseases (Newcastle disease, Infectious Bronchitis)
PHARMACOKINETIC PROPERTIES
- Fosfomycin: Rapidly absorbed after oral administration; bioavailability in poultry is approximately 39.3% with peak plasma concentrations reached within 2 hours. Eliminated rapidly with a half-life of approximately 1.4 hours. Widely distributed throughout body tissues [citation:9].
- Tylosin: Rapidly absorbed from the gastrointestinal tract; achieves high concentrations in respiratory tissues. Widely distributed throughout the body, with good tissue penetration [citation:4].
- Electrolytes: Sodium phosphate and magnesium sulphate are absorbed and utilized for maintaining fluid balance and metabolic functions
DOSAGE & ADMINISTRATION
FOSFOZONE is administered via drinking water. For optimal results, fresh medicated water should be prepared daily.
Recommended Dosage:
- Poultry (Broilers, Layers, Breeders, Turkeys): 1 g per 1-2 liters of drinking water for 3-5 consecutive days [citation:1]
- Alternative Dosage (body weight): 160 mg of the combination per kg body weight per day, equivalent to 0.8 g of FOSFOZONE per 10 kg body weight [citation:1][citation:2]
- Treatment Duration: 3-5 consecutive days [citation:1][citation:2]. For chronic or severe infections, up to 7 days may be required
Administration Guidelines:
- Calculate total daily water consumption based on flock size, age, and environmental temperature
- Dissolve the required amount of FOSFOZONE in a small volume of water, then add to the main drinking water tank
- For use in automatic water proportioners, prepare stock solution according to manufacturer specifications
- Prepare fresh medicated water daily; discard any unused solution after 24 hours [citation:1]
- Ensure medicated water is the sole source of drinking water during treatment
- For best results, administer over 4-8 hours; may withhold water for 1-2 hours before treatment to encourage rapid consumption
- High concentrations of mineral salts in drinking water may interfere with product solubility [citation:8]. Use clean, fresh water for best results.
DRUG INTERACTIONS
- Positive Interactions: Fosfomycin shows positive interactions with beta-lactam antibiotics, aminoglycosides, and anti-staphylococcal agents [citation:2]
- Antagonistic: Avoid concurrent use with other bacteriostatic antibiotics that may cause antagonism
- Synergistic: The combination of fosfomycin and tylosin itself is synergistic; no other significant synergistic interactions documented
CONTRAINDICATIONS & PRECAUTIONS
- Egg production: Do not use in laying hens producing eggs for human consumption [citation:1][citation:2][citation:5]
- Hypersensitivity: Do not use in animals with known hypersensitivity to fosfomycin, tylosin, or macrolides [citation:1][citation:2]
- Severe renal or hepatic impairment: Do not use in animals with severe impaired renal or hepatic function [citation:1][citation:2]
- Dehydrated animals: Respect the dose in dehydrated animals; ensure adequate water intake [citation:2]
- Sensitive species: Do not allow horses, rabbits, hamsters, guinea pigs, or ruminants access to water containing this product
- Keep out of reach of children [citation:1][citation:2]
- When handling the product, avoid inhalation, oral exposure, and direct contact with skin or eyes. Use protective clothing and gloves [citation:2][citation:4]
- Store in a cool, dry place below 25-30°C, protected from direct sunlight [citation:1][citation:2][citation:5]
- Protect from moisture
- Use within 28 days after first opening [citation:2]
ADVERSE REACTIONS
- At recommended doses, the combination is generally well tolerated in poultry [citation:2][citation:5]
- Occasional mild diarrhea may occur during or after treatment [citation:1]
- No adverse effects have been reported when used as directed [citation:5]
- If adverse reactions occur, discontinue use and consult a veterinarian
WITHDRAWAL PERIOD
- Meat (Poultry): 7 days [citation:1][citation:2]. Some formulations recommend 10 days [citation:8]. Always follow local regulatory requirements.
- Eggs: Not for use in laying hens producing eggs for human consumption [citation:1][citation:2][citation:5]. Some formulations allow 5 days withdrawal for eggs [citation:8].
- Note: Withdrawal periods may vary by country; always follow local regulatory requirements
STORAGE
- Store in a cool, dry place below 25-30°C [citation:1][citation:2][citation:5]
- Protect from direct sunlight and moisture [citation:1][citation:2]
- Keep container tightly closed when not in use
- Do not freeze
- Store in original packaging until ready to use
Target Species: Poultry (Broilers, Turkeys, Ducks, Geese, Quail) - Not for use in laying hens producing eggs for human consumption
Pack Sizes: 1 Kg HDPE container
PRODUCT SUMMARY
FOSFOZONE Powder Antibiotic Fosfomycin calcium 20g, Tylosin Tartrate 10g, Fructose 18g, Sodium Phosphate 15g, Magnesium Sulphate 10g per 100g Poultry 1 Kg
FOR VETERINARY USE ONLY
