Product Name: RESPIZONE

Type: Oral Water-Soluble Powder - Mucolytic Agent

COMPOSITION

Each 100 g contains:

• Bromhexine Hydrochloride BP ...... 1 g (1% w/w, 10 mg per gram)
• Tartaric Acid ...... 15 g (15% w/w)

DESCRIPTION

RESPIZONE is a mucolytic respiratory support powder containing bromhexine hydrochloride, a classic expectorant agent widely used in both human and veterinary medicine for the treatment of respiratory conditions characterized by thick, tenacious mucus .

Bromhexine hydrochloride is a semi-synthetic derivative of the alkaloid vasicine. It acts as a potent mucolytic agent that reduces the viscosity of bronchial secretions, facilitating their expectoration and clearing the airways . Tartaric acid is included as a solubilizer and stabilizer to enhance the solubility and bioavailability of bromhexine in drinking water .

MECHANISM OF ACTION

Bromhexine Hydrochloride:

• Acts directly on the bronchial glands to promote the release of lysosomes from mucus-secreting cells, causing depolymerization of mucopolysaccharide fibers in the sputum
• Inhibits the synthesis of acid glycoproteins in mucus glands and goblet cells, reducing the viscosity of secretions
• Stimulates the production of serous bronchial secretions, which dilute the existing thick mucus
• Enhances ciliary activity in the respiratory tract, improving the clearance of infectious material

Synergistic Benefits with Antibiotics:

• Bromhexine increases the concentration of certain antibiotics (especially tetracyclines) in bronchial secretions, enhancing their therapeutic efficacy
• By clearing mucus plugs, it improves the penetration of antimicrobial agents to infected tissues
• Used as an adjunct to antibiotic therapy for faster clinical recovery

INDICATIONS

RESPIZONE is indicated as an adjunctive treatment for respiratory conditions in poultry characterized by thick, tenacious bronchial secretions .

Disease Conditions:

• Chronic Respiratory Disease (CRD) - mycoplasmosis with thick mucus accumulation
• Complex Chronic Respiratory Disease (CCRD) - mixed infections with excessive mucus production
• Infectious Bronchitis (IB) - viral respiratory infection with mucus accumulation
• Newcastle Disease (ND) - respiratory form with mucus obstruction
• Laryngotracheitis (ILT) - to facilitate clearing of airway exudates
• Bacterial Pneumonia - to enhance antibiotic penetration
• Tracheitis and Bronchitis - to reduce mucus viscosity and improve breathing

DOSAGE & ADMINISTRATION

RESPIZONE is administered via drinking water or mixed with feed. For optimal results, fresh medicated water should be prepared daily .

Recommended Dosage:

• Poultry (Broilers, Layers, Breeders, Turkeys): 1 g per liter of drinking water (providing 10 mg bromhexine per liter) for 3-5 consecutive days
• Feed Mixing: 1 kg per ton of feed for 3-5 consecutive days
• Alternative Dosage (body weight): 0.5 mg bromhexine per kg body weight per day

Administration Guidelines:

• Calculate total daily water consumption based on flock size, age, and environmental temperature
• Dissolve the required amount of RESPIZONE in a small volume of water, then add to the main drinking water tank
• For use in automatic water proportioners, prepare stock solution according to manufacturer specifications
• Prepare fresh medicated water daily; discard any unused solution after 24 hours
• Ensure medicated water is the sole source of drinking water during treatment
• For best results, administer over 4-8 hours; may withhold water for 1-2 hours before treatment to encourage rapid consumption
• In acute respiratory infections, RESPIZONE should be given alongside antibiotics or antibacterials for enhanced efficacy

DRUG INTERACTIONS

• Synergistic: Bromhexine increases the concentration of tetracycline-class antibiotics (chlortetracycline, doxycycline, oxytetracycline) in bronchial secretions, enhancing their antimicrobial activity in the respiratory tract .
• Compatible: May be used concurrently with most antibiotics (macrolides, penicillins, aminoglycosides, fluoroquinolones) .
• Contraindicated combination: Do not administer with sodium chloride (NaCl) solution; may cause incompatibility .

CONTRAINDICATIONS & PRECAUTIONS

• Gastric ulcers: Do not administer to animals with ulcerative processes in the digestive tract. Bromhexine may cause gastric irritation .
• Egg production: No withdrawal is necessary for eggs .
• Use with caution in animals with a history of gastric disorders .
• Do not administer with sodium chloride (NaCl) solution .
• Keep out of reach of children
• Store in a cool, dry place below 30°C, protected from direct sunlight
• Protect from moisture
• Use within 28 days after first opening

ADVERSE REACTIONS

• At recommended doses, no adverse reactions have been reported in poultry
• At high doses, may cause mild gastrointestinal discomfort due to gastric irritation
• If adverse reactions occur, discontinue use and consult a veterinarian

WITHDRAWAL PERIOD

• Meat (Poultry): 3-7 days (varies by regulatory jurisdiction; typical withdrawal: 3 days)
• Eggs: No withdrawal necessary; safe for use in egg-producing poultry
• Note: Withdrawal periods may vary by country; always follow local regulatory requirements . Some sources recommend stopping treatment 3 days before slaughter .

STORAGE

• Store in a cool, dry place below 30°C
• Protect from direct sunlight and moisture
• Keep container tightly closed when not in use
• Do not freeze

Target Species: Poultry (Broilers, Layers, Breeders, Turkeys, Ducks, Geese, Quail)

Pack Sizes: 1 Kg HDPE container

PRODUCT SUMMARY
RESPIZONE Powder Antibiotic Bromhexine HCL BP 1g, Tartaric Acid 15g per 100g Poultry 1 Kg

FOR VETERINARY USE ONLY