Product Name: TOLTRAZONE-5

Type: Oral Liquid Solution - Anticoccidial Agent

QAS MANUFACTURING

COMPOSITION

Each 100 ml contains:

• Toltrazuril (innovator specs) ...... 5 g (5% w/v, 50 mg per ml)

DESCRIPTION

TOLTRAZONE-5 is a broad-spectrum anticoccidial oral solution containing toltrazuril, a triazinone derivative with potent activity against all major Eimeria species affecting poultry. Toltrazuril is considered one of the most effective anticoccidial agents available, with activity against both asexual and sexual stages of the coccidian life cycle .

Coccidiosis is a parasitic disease of the intestinal tract caused by protozoa of the genus Eimeria. It is one of the most economically significant diseases in poultry production, causing reduced growth, poor feed conversion, increased mortality, and substantial economic losses worldwide . TOLTRAZONE-5 provides effective control through a unique mechanism of action that disrupts the development of coccidia at multiple stages .

MECHANISM OF ACTION

Toltrazuril acts by interfering with the nuclear division of coccidia, affecting the development of all intracellular stages (merozoites, schizonts, gametocytes). It disrupts the fine structure of the parasite's endoplasmic reticulum and mitochondria, leading to inhibition of nucleic acid and protein synthesis .

Unlike many anticoccidials that only target specific stages of the parasite life cycle, toltrazuril exhibits activity against both asexual and sexual stages, making it highly effective for both treatment and prevention of coccidiosis. It is active against all pathogenic Eimeria species in poultry .

ANTICOCCIDIAL SPECTRUM

TOLTRAZONE-5 is effective against all major Eimeria species affecting poultry:

Chickens:

• Eimeria tenella - caecal coccidiosis
• Eimeria necatrix - intestinal coccidiosis
• Eimeria acervulina - duodenal coccidiosis
• Eimeria maxima - mid-intestinal coccidiosis
• Eimeria brunetti - lower intestinal coccidiosis
• Eimeria mitis, Eimeria praecox

Turkeys:

• Eimeria adenoides, Eimeria meleagrimitis, Eimeria gallopavonis

Geese:

• Eimeria anseris, Eimeria nocens, Eimeria truncata

INDICATIONS

TOLTRAZONE-5 is indicated for the treatment and prevention of coccidiosis in poultry caused by Eimeria species sensitive to toltrazuril .

Chickens:

• Treatment of clinical coccidiosis caused by Eimeria species
• Prevention of coccidiosis in growing birds, especially during the critical 3-6 week period
• Control of coccidiosis outbreaks in broiler and layer flocks

Turkeys:

• Treatment of intestinal and caecal coccidiosis

Geese:

• Treatment of renal and intestinal coccidiosis

DOSAGE & ADMINISTRATION

TOLTRAZONE-5 is administered via drinking water. For optimal results, fresh medicated water should be prepared daily.

Recommended Dosage:

• Chickens (Broilers, Layers, Breeders): 25 mg toltrazuril per kg body weight (equivalent to 0.5 ml of TOLTRAZONE-5 per kg body weight) for 2 consecutive days
• Turkeys: 25 mg toltrazuril per kg body weight (0.5 ml per kg) for 2 consecutive days
• Geese: 25 mg toltrazuril per kg body weight (0.5 ml per kg) for 2 consecutive days
• Drinking Water Concentration: 0.5 ml per liter of drinking water (providing 25 mg toltrazuril per liter) administered for 2 consecutive days

Treatment Schedule:

• Therapeutic Treatment: Administer for 2 consecutive days at the first signs of coccidiosis (bloody droppings, reduced feed intake, diarrhea)
• Preventive Treatment: For flocks with known coccidiosis risk, administer at 3-4 weeks of age for 2 consecutive days
• Severe Outbreaks: In cases of severe coccidiosis, a second 2-day treatment may be administered 5 days after the first treatment

Administration Guidelines:

• Calculate total daily water consumption based on flock size, age, and environmental temperature
• Dissolve the required amount of TOLTRAZONE-5 in a small volume of water, then add to the main drinking water tank
• For use in automatic water proportioners, prepare stock solution according to manufacturer specifications
• Prepare fresh medicated water daily; discard any unused solution after 24 hours
• Ensure medicated water is the sole source of drinking water during treatment
• For best results, administer over 4-8 hours; may withhold water for 1-2 hours before treatment to encourage rapid consumption

EFFICACY DATA

Clinical Efficacy:

• Toltrazuril is recognized as one of the most effective anticoccidial agents, with activity against all pathogenic Eimeria species
• Studies have shown that toltrazuril significantly reduces oocyst shedding, improves weight gain, and reduces mortality in infected birds
• The 2-day treatment protocol provides effective control with minimal stress to birds

Resistance Considerations:

• While toltrazuril remains highly effective, some studies have reported reduced susceptibility in certain Eimeria field isolates. A 2025 study published in Veterinary Medicine and Science evaluated the efficacy of toltrazuril against seven field isolates of Eimeria tenella in broiler chickens. The study found that toltrazuril showed varying efficacy depending on the isolate, with some isolates demonstrating reduced susceptibility .
• In the same study, sulphaclozine (a sulfonamide anticoccidial) showed resistance in all isolates tested, while toltrazuril remained effective against several isolates
• To preserve efficacy, toltrazuril should be used as part of a rotation program with other anticoccidials

CONTRAINDICATIONS & PRECAUTIONS

• Egg production: Do not use in laying hens producing eggs for human consumption
• Breeder flocks: Use with caution in breeder flocks; safety during reproduction has not been fully established
• Hypersensitivity: Do not use in animals with known hypersensitivity to toltrazuril
• Water quality: Do not use water containing high levels of calcium or magnesium, as this may affect solubility
• Keep out of reach of children
• When handling the product, avoid inhalation, oral exposure, and direct contact with skin or eyes
• Store in a cool, dry place below 30°C, protected from direct sunlight
• Do not freeze
• Use within 28 days after first opening

ADVERSE REACTIONS

• At recommended doses, toltrazuril is generally well tolerated in poultry
• Occasional mild diarrhea or reduced water intake may occur
• No significant adverse effects have been reported when used as directed
• If adverse reactions occur, discontinue use and consult a veterinarian

WITHDRAWAL PERIOD

• Meat (Poultry): 21 days for chickens (14-21 days depending on regulatory jurisdiction)
• Meat (Turkeys): 14 days
• Eggs: Not for use in laying hens producing eggs for human consumption
• Note: Withdrawal periods may vary by country; always follow local regulatory requirements

STORAGE

• Store in a cool, dry place below 30°C
• Protect from direct sunlight and freezing
• Keep container tightly closed when not in use
• Do not freeze

Target Species: Poultry (Broilers, Layers, Breeders, Turkeys, Ducks, Geese, Quail)

Pack Sizes: 1 Liter HDPE bottle

PRODUCT SUMMARY
TOLTRAZONE-5 Liquid Anticoccidial Toltrazuril innovator specs 5g per 100ml Poultry 1 Liter

FOR VETERINARY USE ONLY