Product Name: PARAZONE-6.7

Type: Oral Water-Soluble Powder - Antipyretic, Analgesic & Electrolyte Supplement

COMPOSITION

Each 1000 g contains:

• Acetylsalicylic Acid USP ...... 67 g (6.7% w/w, 67 mg per gram)
• Vitamin C BP ...... 200 g (20% w/w, 200 mg per gram)
• Potassium Chloride BP ...... 3 g (0.3% w/w, 3 mg per gram)
• Sodium Citrate BP ...... 7 g (0.7% w/w, 7 mg per gram)

DESCRIPTION

PARAZONE-6.7 is a comprehensive antipyretic, analgesic, and electrolyte supplement specifically formulated for poultry. This multi-component product combines acetylsalicylic acid (aspirin) for fever reduction and pain relief with high-dose vitamin C for antioxidant support and electrolytes (potassium chloride and sodium citrate) to maintain fluid and acid-base balance during stress periods .

Acetylsalicylic acid is a non-steroidal anti-inflammatory drug (NSAID) that reduces fever by inhibiting prostaglandin synthesis in the hypothalamus and provides analgesic effects . Studies in chicks have demonstrated that aspirin has an elimination half-life of approximately 1.68 hours following administration, indicating relatively rapid clearance from the body [citation:1]. Vitamin C is a potent antioxidant that has been shown to significantly decrease the mRNA expression of pro-inflammatory cytokines such as IL-1β, IL-6, and IFN-γ, and enhance total antioxidant status (TAS) in broiler chicks under summer heat stress conditions [citation:2].

MECHANISM OF ACTION

Acetylsalicylic Acid:

• Acts centrally on the hypothalamus to reduce fever by inhibiting prostaglandin synthesis via irreversible cyclooxygenase (COX) inhibition
• Provides analgesic effects, alleviating pain and discomfort associated with illness and inflammation
• Rapidly absorbed after oral administration; pharmacokinetic studies in chicks show an elimination half-life of 1.68 hours with a total body clearance of 0.029 l/h/kg [citation:1]

Vitamin C:

• Potent antioxidant that scavenges reactive oxygen species (ROS) generated during stress and infection
• Dietary vitamin C supplementation (200 mg/kg) significantly decreases hepatic mRNA expression of pro-inflammatory cytokines including IL-1β, IL-6, and IFN-γ in broiler chicks exposed to summer heat stress [citation:2]
• Enhances serum total antioxidant status (TAS) and reduces lipid peroxidation, protecting cellular membranes from oxidative damage [citation:2]
• Supports immune function and aids in tissue repair during recovery [citation:6]

Potassium Chloride & Sodium Citrate:

• Restore electrolyte balance lost during fever, diarrhea, or heat stress
• Maintain acid-base balance through buffering capacity (citrate acts as a weak base)
• Support proper hydration and metabolic function during recovery periods
• Sodium citrate helps stabilize acid-base balance in cases of acidosis [citation:3]

INDICATIONS

PARAZONE-6.7 is indicated for the supportive management of fever, pain, stress, and dehydration in poultry .

Key Indications:

• Fever Reduction - associated with bacterial, viral, and parasitic infections
• Heat Stress Management - during high ambient temperatures; vitamin C has been shown to significantly decrease pro-inflammatory cytokine expression and heat shock protein 70 (HSP70) in broiler chicks exposed to summer heat stress [citation:2]
• Vaccination Support - reduces post-vaccination stress and fever
• Disease Recovery - supports recovery during and after illness with antioxidant and anti-inflammatory support
• Dehydration Support - replenishes electrolytes lost during diarrhea, fever, or heat stress
• Stress Management - during transport, handling, or environmental changes
• Concurrent Therapy - as an adjunct to antibiotic treatment for feverish conditions

BENEFITS

• Rapid Fever Reduction - aspirin helps lower body temperature quickly during febrile conditions [citation:1]
• Anti-inflammatory Action - reduces inflammation associated with infection and stress
• Enhanced Antioxidant Status - vitamin C supplementation significantly increases serum total antioxidant status (TAS) and decreases lipid peroxidation in heat-stressed birds [citation:2]
• Improved Feed Intake - reduces fever-associated anorexia
• Stress Reduction - vitamin C decreases mRNA expression of IL-1β, IL-6, IFN-γ, and HSP70, mitigating the negative effects of heat stress [citation:2]
• Electrolyte Balance - prevents dehydration and maintains metabolic function during recovery

DOSAGE & ADMINISTRATION

PARAZONE-6.7 is administered via drinking water. For optimal results, fresh medicated water should be prepared daily.

Recommended Dosage:

• Poultry (Broilers, Layers, Breeders, Turkeys): 1 g per 1-2 liters of drinking water
• Treatment Duration: 3-5 consecutive days, or as needed during stress periods
• Severe Cases: Up to 2 g per liter of drinking water for the first 24 hours

Administration Guidelines:

• Calculate total daily water consumption based on flock size, age, and environmental temperature
• Dissolve the required amount of PARAZONE-6.7 in a small volume of water, then add to the main drinking water tank
• For use in automatic water proportioners, prepare stock solution according to manufacturer specifications
• Prepare fresh medicated water daily; discard any unused solution after 24 hours
• During heat stress, administer continuously for the duration of the hot period
• When used with antibiotics, administer concurrently for supportive care

SCIENTIFIC EVIDENCE

Heat Stress and Inflammation:

• Research has demonstrated that dietary vitamin C supplementation (200 mg/kg diet) significantly decreases the mRNA expression of pro-inflammatory cytokines including IL-1β, IL-6, and IFN-γ in the liver of broiler chicks exposed to summer heat stress conditions [citation:2].
• Total antioxidant status (TAS) in serum was significantly higher in birds fed vitamin C-supplemented diets, while lipid peroxidation in both serum and liver was significantly decreased [citation:2].
• Heat shock protein 70 (HSP70) expression was also significantly reduced in vitamin C-fed birds, indicating better cellular adaptation to stress [citation:6].

Aspirin Pharmacokinetics in Chicks:

• A pharmacokinetic study in 12-day old chicks administered aspirin (100 mg/kg intraperitoneally) showed an elimination half-life of 1.68 hours, steady-state volume of distribution of 0.079 l/kg, and total body clearance of 0.029 l/h/kg [citation:1].
• The mean residence time was 2.74 hours, indicating relatively rapid clearance, which supports its safety profile when used at recommended doses [citation:5].

CONTRAINDICATIONS & PRECAUTIONS

• Hypersensitivity: Do not use in animals with known hypersensitivity to acetylsalicylic acid (aspirin), salicylates, or any component
• Liver and kidney dysfunction: Use with caution in animals with impaired hepatic or renal function; high doses of aspirin may cause hepatotoxicity and nephrotoxicity
• Bleeding disorders: Use with caution in animals with bleeding disorders as aspirin has antiplatelet effects
• Electrolyte balance: Do not exceed recommended dosage, as excessive electrolyte supplementation may cause imbalances
• Keep out of reach of children
• When handling the product, avoid inhalation, oral exposure, and direct contact with skin or eyes
• Store in a cool, dry place below 25-30°C, protected from direct sunlight
• Protect from moisture
• Use within 28 days after first opening

ADVERSE REACTIONS

• At recommended doses, the product is generally well tolerated in poultry
• Prolonged use at high doses may cause gastrointestinal irritation, mucosal erosion, or bleeding
• Excessive aspirin may cause salicylate toxicity; signs include depression, panting, and metabolic acidosis
• If adverse reactions occur, discontinue use and consult a veterinarian

WITHDRAWAL PERIOD

• Meat (Poultry): 1-3 days (aspirin has a short elimination half-life; consult local regulatory requirements) [citation:1]
• Eggs: Zero days - no withdrawal required for eggs
• Note: Withdrawal periods may vary by country; always follow local regulatory requirements

STORAGE

• Store in a cool, dry place below 25-30°C
• Protect from direct sunlight and moisture
• Keep container tightly closed when not in use
• Do not freeze

Target Species: Poultry (Broilers, Layers, Breeders, Turkeys, Ducks, Geese, Quail)

Pack Sizes: 1 Kg HDPE container

PRODUCT SUMMARY
PARAZONE-6.7 Powder NSAID / Antipyretic Acetylsalicylic acid USP 67g, Vitamin C BP 200g, Potassium chloride BP 3g, Sodium citrate BP 7g per 1000g Poultry 1 Kg

FOR VETERINARY USE ONLY