High-concentration amoxicillin trihydrate soluble powder 70% for poultry and livestock. Contains 700 mg/g amoxicillin for treatment of respiratory, gastrointestinal, and urinary tract infections caused by amoxicillin-sensitive bacteria including E. coli, Salmonella, Pasteurella, and Streptococcus species.
Product Name: AMOXIQAS
Type: Oral Water-Soluble Powder - Aminopenicillin Antibiotic
COMPOSITION
Each gram contains:
- Amoxicillin Trihydrate ...... 700 mg (70% w/w)
Amoxicillin content equivalent to 700 mg amoxicillin activity per gram of product.
DESCRIPTION
AMOXIQAS is a high-concentration water-soluble powder containing amoxicillin trihydrate 70%, a broad-spectrum semisynthetic penicillin antibiotic. Amoxicillin is widely used in veterinary medicine for the treatment of bacterial infections in poultry and livestock due to its excellent pharmacokinetic properties: resistance to gastric acid, good digestive absorption, and favorable tissue distribution [citation:1].
Amoxicillin is a beta-lactam antibiotic that exerts its bactericidal action by interfering with bacterial cell wall synthesis, making it effective against a wide range of gram-positive and gram-negative bacteria [citation:4][citation:8].
MECHANISM OF ACTION
Amoxicillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. This binding inhibits the transpeptidation reaction, preventing the cross-linking of peptidoglycan strands, which are essential for cell wall integrity. The disruption of cell wall synthesis leads to bacterial cell lysis and death [citation:4][citation:8].
Amoxicillin is bactericidal against susceptible organisms and is most effective during the active growth phase of bacteria [citation:5].
ANTIMICROBIAL SPECTRUM
Amoxicillin exhibits broad-spectrum activity against a wide range of gram-positive and gram-negative bacteria [citation:8]:
Gram-Positive Bacteria:
- Staphylococcus spp. (non-penicillinase producing strains)
- Streptococcus spp.
- Clostridium perfringens
- Corynebacterium spp.
- Erysipelothrix rhusiopathiae
- Listeria monocytogenes
Gram-Negative Bacteria:
- Escherichia coli
- Salmonella spp.
- Pasteurella multocida
- Haemophilus spp.
- Klebsiella spp.
- Proteus spp.
- Fusobacterium necrophorum
- Brachyspira hyodysenteriae
Note: Amoxicillin is not effective against penicillinase-producing bacteria (resistant staphylococci) or Mycoplasma species. The addition of a beta-lactamase inhibitor such as clavulanic acid may be required to overcome resistance in penicillinase-producing organisms [citation:9].
INDICATIONS
AMOXIQAS is indicated for the treatment of infections caused by amoxicillin-sensitive bacteria in poultry and livestock [citation:8].
Poultry (Broilers, Layers, Breeders, Turkeys, Ducks, Geese):
- Colibacillosis - Escherichia coli infections causing airsacculitis, pericarditis, perihepatitis, and septicemia [citation:3][citation:9]
- Salmonellosis - including fowl typhoid and paratyphoid infections [citation:9]
- Pasteurellosis - fowl cholera caused by Pasteurella multocida [citation:3][citation:9]
- Necrotic Enteritis - caused by Clostridium perfringens [citation:9]
- Respiratory Infections - including chronic respiratory disease (CRD) complicated by bacterial pathogens [citation:9]
- Infectious Coryza - caused by Avibacterium paragallinarum [citation:9]
- Staphylococcosis - staphylococcal infections [citation:5][citation:6]
- Bacterial Enteritis - diarrhea of bacterial origin [citation:5]
- Omphalitis - yolk sac infection in chicks
Swine:
- Streptococcal Infections - including Streptococcus suis [citation:3]
- Colibacillosis - E. coli infections [citation:5]
- Salmonellosis
- Pasteurellosis
- Erysipelas - caused by Erysipelothrix rhusiopathiae [citation:8]
- MMA Syndrome - mastitis-metritis-agalactia complex [citation:8]
- Swine Dysentery - caused by Brachyspira hyodysenteriae [citation:8]
PHARMACOKINETIC PROPERTIES
- Absorption: Amoxicillin is well absorbed from the gastrointestinal tract. It is resistant to gastric acid, ensuring good bioavailability after oral administration [citation:1][citation:5].
- Distribution: Widely distributed throughout the body tissues, achieving therapeutic concentrations in respiratory tract, gastrointestinal tract, and urinary system [citation:1].
- Elimination: The plasma half-life of amoxicillin is relatively short, approximately 1.68 hours in poultry, resulting in rapid clearance from the body [citation:1]. Excreted primarily in urine.
DOSAGE & ADMINISTRATION
AMOXIQAS is administered via drinking water. For optimal results, fresh medicated water should be prepared daily.
Recommended Dosage:
Poultry (Chickens, Turkeys, Ducks, Geese):
- Body Weight Based: 15-20 mg amoxicillin per kg body weight per day (equivalent to 21-29 mg product per kg body weight per day) for 3-5 consecutive days [citation:1][citation:3][citation:8]
- Water Concentration: 1 g of AMOXIQAS per 4-8 liters of drinking water (providing 700 mg amoxicillin per 4-8 liters) [citation:5]
- Calculation: Each 100 g of AMOXIQAS medicates 400-800 liters of drinking water at the recommended concentration.
- Treatment Duration: 3-5 consecutive days. For severe infections, extend to 5-7 days [citation:3].
Swine:
- Body Weight Based: 10-21 mg amoxicillin per kg body weight per day (equivalent to 15-30 mg product per kg body weight per day) for 3-5 consecutive days [citation:3][citation:8]
Administration Guidelines:
- Calculate total daily water consumption based on flock size, age, and environmental temperature
- Dissolve the required amount of AMOXIQAS in a small volume of water, then add to the main drinking water tank
- For use in automatic water proportioners, prepare stock solution according to manufacturer specifications
- Prepare fresh medicated water daily; discard any unused solution after 24 hours [citation:1]
- Ensure medicated water is the sole source of drinking water during treatment [citation:1]
- For best results, administer over 4-8 hours; may withhold water for 1-2 hours before treatment to encourage rapid consumption
- Thoroughly clean water lines before and after treatment to prevent biofilm accumulation [citation:1]
DRUG INTERACTIONS
- Antagonistic: Do not administer concurrently with bacteriostatic antibiotics (tetracyclines, macrolides, chloramphenicol) as this may result in antagonism [citation:1].
- Avoid: Avoid concurrent use with heavy metals, which may form complexes [citation:5].
- Synergistic: Amoxicillin may be combined with clavulanic acid to overcome beta-lactamase-producing resistant bacteria [citation:9].
CONTRAINDICATIONS & PRECAUTIONS
- Hypersensitivity: Do not use in animals with known hypersensitivity to penicillins or cephalosporins [citation:1][citation:9].
- Egg production: Do not use in laying hens producing eggs for human consumption [citation:1][citation:8].
- Renal impairment: Use with caution in animals with severe renal insufficiency [citation:1].
- Sensitive species: Do not use in rabbits, guinea pigs, hamsters, or gerbils, as fatal gastrointestinal disturbances may occur [citation:1][citation:9].
- Resistance: Use based on susceptibility testing where possible. Inappropriate use may increase the prevalence of resistant bacteria [citation:1].
- Pregnancy: Amoxicillin is generally considered safe during pregnancy and lactation [citation:1].
- Keep out of reach of children
- Store in a cool, dry place below 25°C, protected from direct sunlight and moisture [citation:1]
- Use within 28 days after first opening [citation:1]
ADVERSE REACTIONS
- Allergic reactions may occur rarely in hypersensitive animals, including skin rashes, fever, or anaphylaxis [citation:1].
- Gastrointestinal side effects such as mild diarrhea may occur [citation:1].
- If adverse reactions occur, discontinue use and consult a veterinarian.
WITHDRAWAL PERIOD
- Meat (Poultry): 1 day [citation:1][citation:3]
- Meat (Turkeys): 5 days [citation:3]
- Meat (Ducks): 9 days [citation:3]
- Meat (Swine): 2 days [citation:3] to 15 days (varies by regulatory jurisdiction) [citation:8]
- Eggs: Not for use in laying hens producing eggs for human consumption [citation:1][citation:8]
- Note: Withdrawal periods may vary by country; always follow local regulatory requirements.
STORAGE
- Store in a cool, dry place below 25°C [citation:1].
- Protect from direct sunlight and moisture [citation:8].
- Keep container tightly closed when not in use.
- Do not freeze.
Target Species: Poultry (Broilers, Turkeys, Ducks, Geese, Quail), Swine
Pack Sizes: 1 Kg HDPE container
PRODUCT SUMMARY
AMOXIQAS Powder Antibiotic Amoxicillin Trihydrate 700mg per gram Poultry 1 Kg
FOR VETERINARY USE ONLY