Product Name: LY-QAS

Type: Oral Liquid Solution - Nutraceutical (Enzyme, Vitamin & Herbal Supplement)

COMPOSITION

Each ml contains:

• Lysozyme ...... 40 IU
• Vitamin A ...... 25,000 IU
• Vitamin D3 ...... 5,000 IU
• Vitamin E ...... 15 mg
• Vitamin C ...... 50 mg
• Passiflora incarnata L. fluid extract ...... 10 mg
• Valeriana officinalis L. fluid extract ...... 10 mg
• Tilia cordata Miller fluid extract ...... 5 mg
• Magnesium Chloride ...... 20 mg

DESCRIPTION

LY-QAS is a comprehensive, multi-action liquid nutraceutical that combines the antimicrobial enzyme lysozyme with high-potency vitamins (A, D3, E, C), calming botanical extracts (Passion Flower, Valerian, Linden), and magnesium chloride. This advanced formulation is designed to support immune function, reduce oxidative stress, manage stress responses, and enhance gut health in poultry .

Recent research has demonstrated that lysozyme supplementation significantly improves growth performance, reduces oxidative stress, normalizes cortisol levels, and enhances haematological parameters in broiler chickens challenged with enteric infections . The combination of lysozyme with vitamins and calming botanicals provides a synergistic approach to managing the complex challenges faced by modern poultry production .

MECHANISM OF ACTION

Lysozyme:

• Natural antimicrobial enzyme that hydrolyzes the peptidoglycan layer of bacterial cell walls, particularly effective against gram-positive bacteria
• Studies show lysozyme supplementation significantly improves growth performance and reduces Clostridium perfringens counts in infected birds
• Enhances antioxidant status by increasing catalase (CAT) and superoxide dismutase (SOD) levels while reducing oxidative stress markers (MDA, NO)
• Normalizes stress hormone (cortisol) levels and improves haematological parameters

Vitamins A, D3, E, C:

• Vitamin A: Essential for epithelial integrity, immune function, and reproduction. Deficiency leads to respiratory and digestive tract lesions
• Vitamin D3: Regulates calcium and phosphorus metabolism, essential for bone development and eggshell quality
• Vitamin E: Potent antioxidant that protects cell membranes from oxidative damage and enhances immune response
• Vitamin C: Antioxidant that supports adrenal function and stress response; particularly beneficial during heat stress and disease

Botanical Extracts:

• Passiflora incarnata (Passion Flower): Traditional calming herb with anxiolytic properties; helps reduce stress-induced behaviors
• Valeriana officinalis (Valerian): Known for sedative and calming effects; may help reduce stress responses during handling and transportation
• Tilia cordata (Linden): Traditional calming herb with mild sedative and antispasmodic properties

Magnesium Chloride:

• Essential mineral involved in energy metabolism, nerve function, and muscle contraction
• Helps maintain electrolyte balance and supports stress reduction
• May help prevent hypomagnesemia during periods of stress or high production

SCIENTIFIC EVIDENCE

Lysozyme Efficacy in Broilers:

• A 2025 study published in the Egyptian Journal of Veterinary Sciences evaluated lysozyme supplementation in broiler chickens co-infected with Eimeria and Clostridium perfringens .
• Results showed that lysozyme supplementation significantly improved growth performance, reduced oxidative stress markers (MDA, NO), and increased antioxidant levels (CAT, SOD) .
• Lysozyme treatment normalized cortisol levels and enhanced haematological parameters .
• Quantitative PCR analysis revealed increased GSH gene expression and decreased IL-6 gene expression in lysozyme-treated groups .
• All treatment groups showed increased IL-1β and IgA gene expression, while IgY gene expression was upregulated in lysozyme-treated groups .
• The combination of lysozyme with amoxicillin exhibited the most pronounced improvements in all assessed parameters .

Vitamin C & Stress:

• While poultry can synthesize vitamin C endogenously, supplementation is beneficial during stress conditions such as heat stress, vaccination, and disease

Magnesium in Poultry:

• Magnesium is essential for energy metabolism, nerve signal transmission, and muscle contraction
• Magnesium chloride provides high bioavailability and helps maintain electrolyte balance during stress

INDICATIONS & BENEFITS

LY-QAS is indicated for the management of stress, immune support, and gut health in poultry .

Key Indications:

• Immune Support: Enhances immune function through lysozyme's antimicrobial properties and vitamins A, D3, E, and C
• Stress Management: Botanical extracts (Passion Flower, Valerian, Linden) provide calming effects; vitamin C supports adrenal function
• Heat Stress: Vitamin C and magnesium chloride help maintain electrolyte balance and reduce oxidative stress
• Gut Health: Lysozyme helps control pathogenic bacteria, particularly Clostridium perfringens, while supporting beneficial gut microbiota
• Vaccination Support: Administer before and after vaccination to reduce stress and enhance immune response
• Disease Recovery: Supports recovery during and after antibiotic treatment; research shows lysozyme + amoxicillin combination is highly effective
• Transport & Handling: Calming botanicals help reduce stress during movement and flock rearrangements

DOSAGE & ADMINISTRATION

LY-QAS is administered via drinking water. For optimal results, fresh medicated water should be prepared daily.

Recommended Dosage:

• Poultry (Broilers, Layers, Breeders, Turkeys): 0.5 - 1 ml per liter of drinking water
• Severe Stress or Disease: 1 - 2 ml per liter of drinking water for the first 24-48 hours
• Treatment Duration: 3-5 consecutive days, or as needed during stress periods

Recommended Usage Periods:

• Heat Stress: Administer during periods of high ambient temperature
• Vaccination: Administer 1-2 days before and 2-3 days after vaccination
• Disease Recovery: Administer during and for 3-5 days after antibiotic treatment
• Transport: Administer 1-2 days before and on the day of transport
• Gut Health Support: Administer for 3-5 days during periods of enteric challenge

Administration Guidelines:

• Calculate total daily water consumption based on flock size, age, and environmental temperature
• Dissolve the required amount of LY-QAS directly into the drinking water tank or mixing system
• For use in automatic water proportioners, adjust settings according to manufacturer specifications
• Prepare fresh medicated water daily; discard any unused solution after 24 hours
• For best results, administer over 4-8 hours; may withhold water for 1-2 hours before treatment to encourage rapid consumption

CONTRAINDICATIONS & PRECAUTIONS

• Egg production: Safe for use in laying hens; no withdrawal period required for eggs
• Hypersensitivity: Do not use in animals with known hypersensitivity to lysozyme, any vitamin, or botanical extracts
• Hypervitaminosis: Do not exceed recommended dosage, as excessive fat-soluble vitamins may accumulate and cause toxicity
• Keep out of reach of children
• Store in a cool, dry place below 25°C, protected from direct sunlight
• Protect from freezing
• Shake well before use
• Use within 28 days after first opening

ADVERSE REACTIONS

• At recommended doses, the product is generally well tolerated in poultry
• Excessive intake may lead to mild gastrointestinal upset or hypervitaminosis
• If adverse reactions occur, discontinue use and consult a veterinarian

STORAGE

• Store in a cool, dry place below 25°C
• Protect from direct sunlight and freezing
• Keep container tightly closed when not in use
• Do not freeze

Target Species: Poultry (Broilers, Layers, Breeders, Turkeys, Ducks, Geese, Quail)

Pack Sizes: 1 Liter, 5 Liter HDPE containers

PRODUCT SUMMARY
LY-QAS Liquid Nutraceutical Lysozyme 40 IU, Vitamin A 25,000 IU, Vitamin D3 5,000 IU, Vitamin E 15mg, Vitamin C 50mg, Passiflora incarnata L. fluid extract 10mg, Valeriana officinalis L. fluid extract 10mg, Tilia cordata Miller fluid extract 5mg, Magnesium chloride 20mg per ml Poultry 1L,5L

FOR VETERINARY USE ONLY