Product Name: V.M.C – 813

Type: Oral Liquid Solution - Nutraceutical (Mineral & Vitamin Supplement)

COMPOSITION

Each liter contains:

• Vitamin D3 ...... 2,000 IU
• Calcium (as gluconate and chloride) ...... 20 mg
• Magnesium Sulphate ...... 15 g
• Zinc Chloride ...... 2.82 mg
• Manganese Chloride ...... 1.3 mg

DESCRIPTION

V.M.C – 813 is a comprehensive liquid mineral and vitamin supplement specifically formulated for poultry. This product combines essential minerals—calcium, magnesium, zinc, and manganese—with vitamin D3 to support optimal bone development, eggshell quality, and metabolic function during growth, peak production, and stress periods .

Calcium and phosphorus are the most abundant minerals in the animal body, with 99% of calcium found in the skeleton. Adequate calcium is crucial for skeletal integrity, eggshell formation, muscle contraction, and numerous enzymatic processes . Vitamin D3 is essential for calcium absorption and utilization, working synergistically with calcium to support bone health and eggshell quality .

Magnesium is involved in over 300 enzymatic reactions, including energy metabolism and protein synthesis . Zinc is critical for immune function, skin and feather integrity, and reproductive performance . Manganese is essential for bone formation, cartilage development, and eggshell quality .

MECHANISM OF ACTION

Vitamin D3 (Cholecalciferol):

• Regulates calcium and phosphorus metabolism by increasing intestinal absorption of calcium and phosphorus
• Stimulates calcium-binding protein synthesis in the intestinal mucosa
• Enhances renal reabsorption of calcium and phosphorus
• Essential for bone mineralization and eggshell formation

Calcium:

• Essential component of bone and eggshell formation
• Critical for muscle contraction, nerve transmission, and blood clotting
• Activates various enzymes and hormone secretion
• Calcium gluconate and chloride forms provide high bioavailability

Magnesium:

• Co-factor for over 300 enzymatic reactions, including energy metabolism and protein synthesis
• Essential for normal muscle and nerve function
• Supports calcium absorption and utilization
• Important for maintaining electrolyte balance and reducing stress

Zinc:

• Essential for immune function and antibody production
• Critical for skin integrity, feather development, and wound healing
• Involved in over 200 enzymatic reactions
• Supports reproductive performance and fertility

Manganese:

• Essential for bone formation and cartilage development
• Critical for eggshell quality and shell membrane formation
• Co-factor for enzymes involved in carbohydrate and lipid metabolism
• Supports antioxidant defense through superoxide dismutase (Mn-SOD) activation

INDICATIONS & BENEFITS

V.M.C – 813 is indicated for the prevention and correction of mineral deficiencies and support of calcium metabolism in poultry .

Layer Chickens:

• Eggshell Quality: Calcium and vitamin D3 support strong eggshell formation, reducing cracked and thin-shelled eggs
• Cage Layer Fatigue: Supports calcium mobilization and bone health, reducing the incidence of cage layer fatigue and osteoporosis
• Peak Production: Helps meet the increased calcium demand during peak egg production

Broiler Chickens:

• Skeletal Development: Supports rapid bone growth and mineralization, reducing the incidence of leg problems and rickets
• Muscle Function: Calcium and magnesium support proper muscle contraction and nerve function

Breeder Chickens:

• Fertility and Hatchability: Zinc and manganese support reproductive performance and embryo development
• Chick Quality: Adequate calcium and trace minerals improve chick viability

Stress Management:

• Heat Stress: Magnesium helps maintain electrolyte balance and reduces stress responses
• Vaccination: Zinc supports immune function and antibody response
• Transport and Handling: Helps maintain mineral balance during stressful periods

Deficiency Correction:

• Calcium Deficiency: Characterized by soft bones (rickets), thin eggshells, and reduced production
• Magnesium Deficiency: Characterized by nervousness, muscle tremors, and poor growth
• Zinc Deficiency: Characterized by poor feathering, skin lesions, and reduced immunity
• Manganese Deficiency: Characterized by perosis (slipped tendon), poor eggshell quality, and reduced hatchability

SCIENTIFIC EVIDENCE

Calcium and Vitamin D3 in Layers:

• Research has consistently demonstrated that adequate calcium and vitamin D3 supplementation is essential for optimal eggshell quality in laying hens
• Vitamin D3 enhances calcium absorption from the intestine and mobilization from bone stores

Magnesium in Poultry:

• Magnesium is essential for energy metabolism, nerve function, and stress reduction in poultry

Zinc in Poultry:

• Zinc supplementation has been shown to improve immune function, enhance antibody response to vaccination, and support skin and feather integrity

Manganese in Poultry:

• Manganese is critical for eggshell quality, with deficiencies leading to thin, cracked shells and reduced hatchability
• Manganese activates enzymes involved in the formation of the eggshell membrane and mineralization

DOSAGE & ADMINISTRATION

V.M.C – 813 is administered via drinking water. For optimal results, fresh medicated water should be prepared daily.

Recommended Dosage:

• Poultry (Broilers, Layers, Breeders, Turkeys): 0.5 - 1 ml per liter of drinking water
• Prevention: 0.5 ml per liter of drinking water, administered 2-3 times per week
• Treatment of Deficiencies: 1 ml per liter of drinking water for 5-7 consecutive days
• Stress Periods: 1 ml per liter of drinking water for 3-5 days during vaccination, heat stress, or peak production
• Calculation: Each 5 liter container treats approximately 5,000-10,000 liters of drinking water at recommended concentrations

Recommended Usage Periods:

• Layers at Onset of Lay: Administer for 5-7 days as birds come into production to support early eggshell quality
• Layers During Peak Production: Administer for 3-5 days monthly to maintain eggshell quality and prevent cage layer fatigue
• Layers in Late Production: Administer for 5-7 days to support bone health and eggshell quality as birds age
• Broilers: Administer for 3-5 days during rapid growth phases (0-7 days, 14-21 days, 28-35 days) to support skeletal development
• Breeders: Administer for 5-7 days before and during the breeding season to support fertility and hatchability
• Heat Stress: Administer during periods of high ambient temperature to maintain electrolyte balance
• Vaccination: Administer 1-2 days before and 2-3 days after vaccination to support immune response

Administration Guidelines:

• Calculate total daily water consumption based on flock size, age, and environmental temperature
• Dissolve the required amount of V.M.C – 813 directly into the drinking water tank or mixing system
• For use in automatic water proportioners, adjust settings according to manufacturer specifications
• Prepare fresh medicated water daily; discard any unused solution after 24 hours
• For best results, administer over 4-8 hours; may withhold water for 1-2 hours before treatment to encourage rapid consumption

CONTRAINDICATIONS & PRECAUTIONS

• Egg production: Safe for use in laying hens; no withdrawal period required for eggs
• Hypercalcemia: Do not exceed recommended dosage, as excessive calcium may interfere with phosphorus absorption and cause soft tissue calcification
• Sensitive species: Use with caution in rabbits, hamsters, guinea pigs, or horses; consult a veterinarian before use
• Hypersensitivity: Do not use in animals with known hypersensitivity to any component
• Keep out of reach of children
• Store in a cool, dry place below 25°C, protected from direct sunlight
• Protect from freezing
• Shake well before use
• Use within 28 days after first opening

ADVERSE REACTIONS

• At recommended doses, the product is generally well tolerated in poultry
• Excessive intake may lead to hypercalcemia or mineral imbalances
• If adverse reactions occur, discontinue use and consult a veterinarian

STORAGE

• Store in a cool, dry place below 25°C
• Protect from direct sunlight and freezing
• Keep container tightly closed when not in use
• Do not freeze

Target Species: Poultry (Broilers, Layers, Breeders, Turkeys, Ducks, Geese, Quail)

Pack Sizes: 5 Liter HDPE container

PRODUCT SUMMARY
V.M.C – 813 Liquid Nutraceutical Vitamin D3 2,000 IU, Calcium 20 mg, Magnesium Sulphate 15g, Zinc chloride 2.82 mg, Manganese chloride 1.3 mg per liter Poultry 5L

FOR VETERINARY USE ONLY