Product Name: HEPAQAS

Type: Oral Liquid Solution - Nutraceutical (Hepatoprotective & Metabolic Support)

COMPOSITION

Each ml contains:

• Sorbitol ...... 350 mg
• Carnitine Hydrochloride ...... 90 mg
• Choline Chloride ...... 60 mg
• Betaine ...... 30 mg
• DL-Methionine ...... 25 mg
• Silybum marianum (Milk Thistle) Extract ...... 20 mg
• Cynara scolimus (Artichoke) Extract ...... 0.8 mg
• Peumus boldu (Boldo) Extract ...... 0.8 mg

DESCRIPTION

HEPAQAS is a comprehensive liquid hepatoprotective and metabolic support supplement specifically formulated for poultry. This advanced formulation combines lipotropic agents (carnitine, choline, betaine, methionine) with natural hepatoprotective herbal extracts (Milk Thistle, Artichoke, Boldo) and the mild laxative sorbitol to support liver function, enhance fat metabolism, and promote detoxification during periods of stress, disease recovery, and high production .

The liver is the central metabolic organ in poultry, responsible for nutrient metabolism, detoxification, and bile production. During periods of high production, stress, or disease, hepatic function can become compromised, leading to reduced performance, fatty liver syndrome, and increased susceptibility to infections. HEPAQAS is designed to support optimal liver function and metabolic efficiency .

MECHANISM OF ACTION

Lipotropic Agents (Fat Metabolism Support):

• Carnitine: Essential for transport of long-chain fatty acids into mitochondria for beta-oxidation, promoting fat utilization and preventing hepatic lipid accumulation
• Choline: Precursor to phosphatidylcholine, a key component of very-low-density lipoproteins (VLDL) required for fat export from the liver; prevents fatty liver syndrome
• Betaine: Methyl donor that supports methionine metabolism and lipid mobilization; acts as an osmolyte to protect cells from osmotic stress
• Methionine: Essential amino acid involved in methylation reactions and glutathione synthesis; supports detoxification pathways

Hepatoprotective Herbal Extracts:

• Silybum marianum (Milk Thistle): Contains silymarin, a flavonolignan complex with antioxidant and hepatoprotective properties. Silymarin stabilizes hepatocyte membranes, stimulates protein synthesis, and protects against oxidative damage
• Cynara scolimus (Artichoke): Contains cynarin and chlorogenic acid; stimulates bile production and flow (choleretic effect), aids in fat digestion, and provides antioxidant protection
• Peumus boldu (Boldo): Contains boldine, an alkaloid with choleretic, anti-inflammatory, and antioxidant properties; supports bile secretion and liver function

Sorbitol:

• Mild osmotic laxative that promotes hydration and gentle intestinal cleansing
• Supports elimination of metabolic waste products
• May aid in reducing hepatic fat accumulation

INDICATIONS & BENEFITS

HEPAQAS is indicated for the support of liver function and fat metabolism in poultry during periods of increased metabolic demand .

Layer Chickens:

• Fatty Liver Syndrome Prevention: Supports fat metabolism and prevents hepatic lipid accumulation, particularly in high-producing layers
• Peak Production Support: Enhances metabolic efficiency during periods of high egg production
• Egg Quality: Improved liver function supports better eggshell quality and yolk pigmentation

Broiler Chickens:

• Rapid Growth Support: Supports metabolic efficiency during intensive growth periods
• Feed Conversion: Enhanced fat utilization may improve feed conversion ratio
• Liver Health: Protects against hepatic stress associated with high-energy diets

Disease Recovery:

• Post-Antibiotic Support: Supports liver detoxification following antibiotic treatment
• Mycotoxin Exposure: Hepatoprotective properties help mitigate the effects of dietary mycotoxins
• Metabolic Disorders: Supports recovery from hepatic and metabolic disturbances

Stress Management:

• Heat Stress: Supports metabolic function during high ambient temperatures
• Vaccination: Enhances metabolic resilience during vaccination periods
• Transport and Handling: Supports liver function during stressful events

Detoxification Support:

• Enhances hepatic detoxification pathways
• Supports elimination of metabolic waste products
• May aid in recovery from toxic insults

SCIENTIFIC EVIDENCE

Milk Thistle (Silymarin) in Poultry:

• Research has demonstrated that silymarin supplementation improves liver function parameters, reduces oxidative stress, and enhances growth performance in broiler chickens
• Silymarin has been shown to protect against mycotoxin-induced liver damage and fatty liver syndrome in laying hens

Artichoke Extract in Poultry:

• Artichoke extract has demonstrated choleretic effects, increasing bile production and flow, which aids in fat digestion and elimination of waste products

Boldo Extract:

• Boldine, the primary alkaloid in Boldo, exhibits hepatoprotective, anti-inflammatory, and antioxidant properties

Lipotropic Agents:

• Choline, betaine, carnitine, and methionine are well-established lipotropic agents that prevent fat accumulation in the liver by promoting fat transport and oxidation
• Studies have shown that betaine supplementation improves growth performance and reduces abdominal fat deposition in broilers

DOSAGE & ADMINISTRATION

HEPAQAS is administered via drinking water. For optimal results, fresh medicated water should be prepared daily.

Recommended Dosage:

• Poultry (Broilers, Layers, Breeders, Turkeys): 0.5 - 1 ml per liter of drinking water
• Prevention: 0.5 ml per liter of drinking water, administered 2-3 times per week
• Treatment: 1 ml per liter of drinking water for 5-7 consecutive days
• Severe Hepatic Stress: 1.5 - 2 ml per liter of drinking water for the first 3-5 days
• Calculation: Each 1 liter container treats approximately 1,000-2,000 liters of drinking water at recommended concentrations

Recommended Usage Periods:

• Layers at Onset of Lay: Administer for 5-7 days as birds come into production to support metabolic transition
• Layers During Peak Production: Administer for 3-5 days monthly to prevent fatty liver syndrome
• Layers in Late Production: Administer for 5-7 days to support liver function as birds age
• Broilers: Administer for 3-5 days during the finisher phase to support fat metabolism
• Post-Antibiotic Treatment: Administer for 5-7 days following antibiotic therapy to support liver detoxification
• Mycotoxin Risk Periods: Administer continuously during periods of suspected mycotoxin exposure
• Heat Stress: Administer during periods of high ambient temperature to support metabolic function

Administration Guidelines:

• Calculate total daily water consumption based on flock size, age, and environmental temperature
• Dissolve the required amount of HEPAQAS directly into the drinking water tank or mixing system
• For use in automatic water proportioners, adjust settings according to manufacturer specifications
• Prepare fresh medicated water daily; discard any unused solution after 24 hours
• For best results, administer over 4-8 hours; may withhold water for 1-2 hours before treatment to encourage rapid consumption

CONTRAINDICATIONS & PRECAUTIONS

• Egg production: Safe for use in laying hens; no withdrawal period required for eggs
• Hypersensitivity: Do not use in animals with known hypersensitivity to any component
• Sorbitol: High doses may cause mild laxative effects; adhere to recommended dosage
• Sensitive species: Use with caution in rabbits, hamsters, guinea pigs, or horses; consult a veterinarian before use
• Keep out of reach of children
• Store in a cool, dry place below 25°C, protected from direct sunlight
• Protect from freezing
• Shake well before use
• Use within 28 days after first opening

ADVERSE REACTIONS

• At recommended doses, the product is generally well tolerated in poultry
• Excessive intake may cause mild diarrhea due to sorbitol content
• If adverse reactions occur, discontinue use and consult a veterinarian

STORAGE

• Store in a cool, dry place below 25°C
• Protect from direct sunlight and freezing
• Keep container tightly closed when not in use
• Do not freeze

Target Species: Poultry (Broilers, Layers, Breeders, Turkeys, Ducks, Geese, Quail)

Pack Sizes: 1 Liter, 5 Liter HDPE containers

PRODUCT SUMMARY
HEPAQAS Liquid Nutraceutical Sorbitol 350mg, Carnitine HCl 90mg, Choline chloride 60mg, Betaine 30mg, DL-methionine 25mg, Silybum marianum extract 20mg, Cynara scolimus extract 0.8mg, Peumus boldu extract 0.8mg per ml Poultry 1L,5L

FOR VETERINARY USE ONLY