Product Name: SELVIT - E

Type: Oral Solution - Nutraceutical (Vitamin & Mineral Supplement)

COMPOSITION

Each ml contains:

• All-rac-alpha-Tocopheryl Acetate (Vitamin E) ...... 250 IU
• Sodium Selenite ...... 450 µg (micrograms)

DESCRIPTION

SELVIT - E is a liquid oral supplement combining vitamin E and selenium, two essential nutrients that work synergistically to support antioxidant defense, immune function, and overall health in poultry. This formulation is designed to prevent and correct deficiencies that can lead to serious metabolic disorders .

Vitamin E (tocopherol) and selenium are critical components of the body's antioxidant defense system. They function synergistically to protect cell membranes from oxidative damage caused by free radicals . Selenium is an essential component of the enzyme glutathione peroxidase (GSH-Px), which converts harmful peroxides into harmless alcohols. Vitamin E acts as a chain-breaking antioxidant, preventing lipid peroxidation in cell membranes .

MECHANISM OF ACTION

Vitamin E (All-rac-alpha-Tocopheryl Acetate):

• Acts as a chain-breaking antioxidant, protecting cell membranes from lipid peroxidation
• Converts free radicals into hydroperoxides, which are then detoxified by selenium-dependent glutathione peroxidase
• Supports immune function by enhancing antibody production and lymphocyte proliferation
• Essential for nervous system development, muscle function, and reproductive health

Selenium (as Sodium Selenite):

• Essential component of glutathione peroxidase (GSH-Px), which reduces hydrogen peroxide and organic peroxides to water and alcohols
• Supports selenoprotein synthesis, which plays critical roles in redox regulation and antioxidant defense
• Enhances immune response, including immunoglobulin production and cytokine expression
• Plays a vital role in thyroid hormone metabolism and cellular growth

Synergistic Action:

• Vitamin E and selenium work together in a complementary manner: vitamin E prevents the initiation of lipid peroxidation, while selenium-dependent glutathione peroxidase neutralizes existing peroxides
• Studies show that the combination significantly improves antioxidant capacity and immune function compared to either nutrient alone
• Research confirms that vitamin E and selenium synergistically affect plasma immunoglobulin levels and splenic cytokine expression (TNF-α, IFN-γ, IL-2, IL-10)
• The inclusion of 100 mg/kg vitamin E with 0.3 mg/kg selenium effectively supports the immune system through regulation of cytokine expression and immunoglobulin levels

INDICATIONS

SELVIT - E is indicated for the prevention and treatment of vitamin E and selenium deficiencies in poultry .

Deficiency Conditions:

• Nutritional Myopathy - also known as white muscle disease or muscular dystrophy, characterized by skeletal (especially breast), cardiac, and smooth muscle degeneration. Lesions appear as pale foci or streaking of the musculature . In poultry, selenium deficiency is the most common cause, while vitamin E deficiency when accompanied by sulfur amino acid deficiency causes myopathy in chicks by approximately 4 weeks of age .
• Exudative Diathesis - characterized by subcutaneous edema, particularly in the breast, abdomen, and neck regions, resulting from increased capillary permeability
• Encephalomalacia (Crazy Chick Disease) - vitamin E deficiency-induced neurological disorder affecting 2-5 week old chicks, characterized by ataxia, head tremors, and paralysis
• Pancreatic Fibrosis - degeneration of pancreatic tissue due to selenium deficiency
• Reduced Fertility and Hatchability - in breeding flocks, deficiencies impair reproduction and embryo development

Key Indications:

• Prevention of Deficiency Diseases: Nutritional myopathy, exudative diathesis, and encephalomalacia in young birds
• Stress Management: Supports antioxidant defense during heat stress, vaccination, and disease recovery
• Immune Support: Enhances antibody production and immune cell function
• Growth and Performance: Supports normal growth and feed efficiency
• Reproductive Support: Improves fertility and hatchability in breeding flocks
• Recovery from Mycotoxin Exposure: Selenium and vitamin E help mitigate oxidative damage caused by mycotoxins

SCIENTIFIC EVIDENCE

Vitamin E and Selenium Synergy:

• A study published in BMC Veterinary Research demonstrated that the combination of 100 mg/kg vitamin E with 0.3 mg/kg selenium significantly enhanced immune response in broiler chickens, with the synergistic effect evident in plasma IgM levels and splenic cytokine expression (TNF-α, IFN-γ, IL-2, IL-10)
• The combination effectively supported the immune system through regulation of cytokine expression and immunoglobulin levels more effectively than using either nutrient alone

Heat Stress Management:

• A 2025 study published in Poultry Science confirmed that vitamin E and selenium supplementation supports broiler performance under heat stress conditions. Birds receiving adequate vitamin E (36-60 ppm) with organic selenium demonstrated improved feed conversion ratio and growth performance
• Vitamin E and selenium serve as essential components of the antioxidant defense system, functioning synergistically to mitigate oxidative stress caused by heat

Nutritional Myopathy Prevention:

• In many parts of the world, poultry feeds are supplemented with selenium at 0.1–0.3 ppm to prevent selenium deficiency and subsequent nutritional myopathy
• Vitamin E deficiency, when accompanied by sulfur amino acid deficiency, causes nutritional myopathy in chicks by approximately 4 weeks of age

DOSAGE & ADMINISTRATION

SELVIT - E is administered via drinking water. For optimal results, fresh medicated water should be prepared daily.

Recommended Dosage:

• Poultry (Broilers, Layers, Breeders, Turkeys, Ducks, Geese): 0.5 - 1 ml per liter of drinking water
• Treatment of Deficiencies: 1 ml per liter of drinking water for 3-5 consecutive days
• Prevention: 0.5 ml per liter of drinking water, administered 2-3 times per week or during stress periods
• Severe Deficiencies: 1-1.5 ml per liter of drinking water for 5-7 consecutive days
• Calculation: Each 1 liter container treats approximately 1,000-2,000 liters of drinking water at recommended concentrations

Recommended Usage Periods:

• Broiler Chickens: Administer for 3-4 days during starter phase (0-14 days) and during periods of rapid growth or stress
• Layer Chickens: Administer for 3-5 days at the onset of lay and during peak production to support reproductive health
• Breeder Chickens: Administer for 5-7 days before and during the breeding season to improve fertility and hatchability
• Heat Stress: Administer during periods of high ambient temperature to support antioxidant defense
• Vaccination: Administer 1-2 days before and 2-3 days after vaccination to support immune response
• Disease Recovery: Administer during and for 3-5 days after antibiotic treatment

Administration Guidelines:

• Calculate total daily water consumption based on flock size, age, and environmental temperature
• Dissolve the required amount of SELVIT - E directly into the drinking water tank or mixing system
• For use in automatic water proportioners, prepare stock solution according to manufacturer specifications
• Prepare fresh medicated water daily; discard any unused solution after 24 hours
• For best results, administer over 4-8 hours; may withhold water for 1-2 hours before treatment to encourage rapid consumption
• Thoroughly clean water lines before and after treatment to prevent biofilm accumulation

WARNING: SELENIUM TOXICITY

CRITICAL SAFETY WARNING: DO NOT EXCEED RECOMMENDED DOSAGE

• Selenium is toxic if administered in excess. Do not exceed the recommended dose .
• Selenium toxicity may cause: reduced feed intake, poor growth, liver damage, and in severe cases, mortality .
• The safe supplementation level for selenium in poultry feed is 0.1–0.3 ppm .
• This product should be used as part of a complete nutritional program; do not use with other selenium-containing supplements without veterinary consultation .

CONTRAINDICATIONS & PRECAUTIONS

• Selenium toxicity: Do not exceed recommended dosage. Selenium is toxic in excess and can cause poisoning
• Hypersensitivity: Do not use in animals with known hypersensitivity to vitamin E, selenium, or any component
• Metal antagonism: Arsenic, zinc, copper, and other metals are antagonistic to selenium, and exposure to these metals may precipitate deficiency outbreaks
• Egg production: Safe for use in laying hens; no withdrawal period required for eggs when used at recommended levels
• Sensitive species: Use with caution in rabbits, hamsters, guinea pigs, or horses; consult a veterinarian before use
• Keep out of reach of children
• Store in a cool, dry place below 25°C, protected from direct sunlight
• Protect from freezing
• Shake well before use
• Use within 28 days after first opening

ADVERSE REACTIONS

• At recommended doses, the product is generally well tolerated in poultry
• Excessive intake may lead to selenium toxicity: reduced feed intake, poor growth, and liver damage
• If adverse reactions occur, discontinue use and consult a veterinarian

WITHDRAWAL PERIOD

• Meat (Poultry): Zero days - no withdrawal period required when used according to label directions
• Eggs: Zero days - no withdrawal period required when used according to label directions
• Note: Withdrawal periods may vary by country; always follow local regulatory requirements

STORAGE

• Store in a cool, dry place below 25°C
• Protect from direct sunlight and freezing
• Keep container tightly closed when not in use
• Do not freeze

Target Species: Poultry (Broilers, Layers, Breeders, Turkeys, Ducks, Geese, Quail)

Pack Sizes: 1 Liter, 5 Liter HDPE containers

PRODUCT SUMMARY
SELVIT - E Oral Solution Nutraceutical All-rac-alpha-Tocopheryl acetate (Vitamin E) 250 IU, Sodium selenite 450 µg per ml Poultry 1L,5L

FOR VETERINARY USE ONLY