Product Name: FROMPRO- ACID PH

Type: Oral Liquid - Organic Acid Blend (Water Acidifier)

COMPOSITION

Each liter contains:

• Formic Acid ...... 320,000 mg (320 g)
• Acetic Acid ...... 150,000 mg (150 g)
• Citric Acid ...... 50,000 mg (50 g)
• Lactic Acid ...... 50,000 mg (50 g)
• Calcium Propionate ...... 30,000 mg (30 g)
• Malic Acid ...... 20,000 mg (20 g)
• Tartaric Acid ...... 20,000 mg (20 g)
• Copper Sulphate ...... 30,000 mg (30 g)

DESCRIPTION

FROMPRO- ACID PH is a concentrated blend of short-chain and hydroxy organic acids specifically formulated for poultry drinking water acidification. This synergistic combination provides potent antimicrobial activity, lowers gastrointestinal pH, enhances nutrient digestion, and supports overall gut health as an effective alternative to antibiotic growth promoters

Organic acids have emerged as promising alternatives to antibiotic growth promoters in poultry production, especially following the European Union's 2006 ban on antibiotics as growth promoters

This product combines formic, acetic, propionic, lactic, citric, malic, and tartaric acids with copper sulphate to achieve maximal beneficial effects through multiple mechanisms of action

MECHANISM OF ACTION

Antimicrobial Activity:

• In their undissociated form, organic acids are lipid-soluble and can penetrate bacterial cell walls
• Once inside the bacterial cell (pH ~7), the acid dissociates, releasing hydrogen ions (H⁺)
• The bacterial cell expends enormous energy to expel H⁺ ions, leading to cell death
• This mechanism is particularly effective against acid-intolerant pathogens such as E. coli, Salmonella, and Campylobacter

Gastrointestinal pH Reduction:

• Acidified drinking water reduces pH in the crop, proventriculus, and gizzard
• Lower pH activates pepsinogen to pepsin, enhancing protein digestion
• Creates an unfavorable environment for pathogenic bacteria while promoting beneficial lactic acid bacteria

Enhanced Nutrient Digestibility:

• Organic acids increase villus height, width, and area in the duodenum, jejunum, and ileum, improving nutrient absorption surface area
• Activate digestive enzymes and improve feed digestibility
• Some acids (citric, fumaric, malic) are intermediates in the Krebs cycle, providing an alternative energy source

Copper Sulphate Synergy:

• Copper provides additional antimicrobial activity against bacteria and fungi
• Works synergistically with organic acids to enhance pathogen control

INDICATIONS & BENEFITS

FROMPRO- ACID PH is indicated for drinking water acidification to improve gut health and overall performance in poultry

Key Benefits:

• Enhanced Growth Performance: Studies show organic acid supplementation significantly improves final body weight, average daily gain, and feed conversion ratio (FCR) in broilers
• Pathogen Reduction: Effectively inhibits Salmonella, E. coli, and Campylobacter in the gastrointestinal tract
• Improved Gut Health: Increases villus height and crypt depth, enhancing nutrient absorption
• Immune Support: Boosts immune response and increases antibody titers against Newcastle disease (ND) and infectious bronchitis (IB)
• Water Quality: Reduces biofilm formation and microbial contamination in drinking water lines
• Economic Benefits: Continuous water acidification has been shown to provide positive return on investment (ROI 13.3) in broiler production

Target Pathogens:

• Escherichia coli - colibacillosis prevention
• Salmonella spp. - salmonellosis prevention
• Campylobacter spp.
• Clostridium perfringens - necrotic enteritis prevention
• Fungi and Mold - feed and water preservation

SCIENTIFIC EVIDENCE

2025 Study on Organic Acid Water Acidification:

• A 2025 study published in the Turkish Journal of Veterinary & Animal Sciences evaluated the effects of organic acid (formic acid) supplemented water at different pH levels on broiler performance
• Results showed that broilers receiving organic acid in water at pH 6.8 exhibited significantly higher growth performance and economic viability
• Water at pH 5.8 supplemented with organic acid improved immune responses, reflected by higher Newcastle disease (ND) and infectious bronchitis (IB) antibody titers
• The study concluded that organic acid supplementation in water at pH 6.8 optimizes growth performance and productivity

2025 Review on Organic Acids in Poultry:

• A comprehensive review published in the National Institutes of Health (PMC) confirmed that organic acids improve feed palatability, reduce gastrointestinal pH, activate digestive enzymes, and inhibit pathogenic microorganisms while preserving beneficial microflora
• The review concluded that organic acids support overall bird health and productivity traits, contributing to economic performance and profitability in poultry farming

2024 Comprehensive Review:

• A 2024 review article in Agriculture journal confirmed that organic acids improve growth performance parameters and carcass traits, promote nutrient utilization, boost immune response, and inhibit pathogenic bacteria in poultry

DOSAGE & ADMINISTRATION

FROMPRO- ACID PH is administered via drinking water. The dosage should be adjusted based on water pH and quality.

Recommended Dosage:

• Poultry (Broilers, Layers, Breeders, Turkeys): 0.5 - 1 ml per liter of drinking water
• Target pH: Adjust dosage to achieve drinking water pH between 3.5 and 4.0 for optimal antimicrobial activity
• Continuous Use: 0.5 ml per liter throughout the production cycle
• Pulsed Use: 1 ml per liter for 6-8 hours daily or 2-3 days per week
• Calculation: Each 25 kg container treats approximately 25,000-50,000 liters of drinking water

Recommended Usage Periods:

• Continuous Acidification: Administer throughout the entire production cycle for optimal growth performance and economic returns
• Partial Acidification: Administer during starter phase (0-14 days) and during stress periods (vaccination, heat stress)
• Post-Antibiotic: Administer for 5-7 days following antibiotic treatment to restore gut health
• Water Line Cleaning: Use at higher concentration (2-3 ml/L) for 24 hours between flocks to clean water lines and remove biofilm

Administration Guidelines:

• Test water pH before treatment and adjust dosage to achieve target pH (3.5-4.0)
• Use proportioner or dosing pump for accurate administration
• Prepare fresh medicated water daily; discard any unused solution after 24 hours
• Do not mix with alkaline substances or medications
• Monitor water pH regularly using pH test strips or meter
• Avoid use with chlorinated water unless allowed to dechlorinate first

CONTRAINDICATIONS & PRECAUTIONS

• Corrosive: This product is corrosive. Avoid contact with skin, eyes, and clothing. Use protective equipment (gloves, goggles) when handling
• Do not mix: Do not mix with alkaline substances, medications, or vitamins in concentrated form
• Metal equipment: Prolonged exposure may corrode metal water lines; use plastic or stainless steel components where possible
• Egg production: Safe for use in laying hens; no withdrawal period required for eggs when used at recommended levels
• Keep out of reach of children
• Store in a cool, dry place below 25°C, protected from direct sunlight and freezing
• Keep container tightly closed when not in use
• Use within 12 months of manufacture; use within 28 days after first opening

ADVERSE REACTIONS

• At recommended doses, the product is generally well tolerated in poultry
• Over-acidification may cause reduced water intake; monitor water consumption during initial use
• If adverse reactions occur, discontinue use and consult a veterinarian

WITHDRAWAL PERIOD

• Meat (Poultry): Zero days - no withdrawal period required
• Eggs: Zero days - no withdrawal period required

STORAGE

• Store in a cool, dry place below 25°C
• Protect from direct sunlight and freezing
• Keep container tightly closed when not in use
• Do not freeze

Target Species: Poultry (Broilers, Layers, Breeders, Turkeys, Ducks, Geese, Quail)

Pack Sizes: 25 kg HDPE container

PRODUCT SUMMARY
FROMPRO- ACID PH Liquid Nutraceutical Formic Acid 320,000 mg, Acetic Acid 150,000 mg, Citric Acid 50,000 mg, Lactic Acid 50,000 mg, Calcium Propionate 30,000 mg, Malic Acid 20,000 mg, Tartaric Acid 20,000 mg, Copper Sulphate 30,000 mg per liter Poultry 25kg

FOR VETERINARY USE ONLY