Product Name: QASTOX PLATINUM

Type: Feed Additive Powder - Yeast-Based Mycotoxin Binder

COMPOSITION

Each gram contains:

• Mannan-oligosaccharides (MOS) ...... from yeast cell walls
• Bentonite-Montmorillonite ...... highly porous clay mineral
• Oil ...... lipid component for enhanced binding
• Artichoke Extract ...... (Cynara scolymus) standardized extract

DESCRIPTION

QASTOX PLATINUM is an advanced, next-generation mycotoxin binder that combines the synergistic power of organic and inorganic binding agents. This premium formulation integrates yeast cell wall derivatives (mannan-oligosaccharides) with high-porosity clay minerals (bentonite-montmorillonite), enhanced with artichoke extract to provide comprehensive protection against the full spectrum of mycotoxins found in animal feed [citation:1].

Mycotoxins are toxic secondary metabolites produced by fungi that contaminate animal feed ingredients, leading to significant economic losses through reduced productivity, immunosuppression, and impaired reproductive performance. QASTOX PLATINUM addresses this challenge through a multi-faceted approach that not only binds mycotoxins in the gastrointestinal tract but also supports the body's natural detoxification processes [citation:1].

MECHANISM OF ACTION

1. Yeast Cell Wall Components (Mannan-oligosaccharides):

• MOS derived from yeast cell walls have demonstrated high binding capacity for aflatoxins (85-96%) and moderate binding for ochratoxin (54-55%) [citation:1]
• The fibrous network structure of β-glucans creates numerous binding sites for non-polar mycotoxins such as zearalenone (ZEA), fumonisins (FUM), and trichothecenes [citation:1]
• Provides prebiotic effects, supporting beneficial gut microbiota and competitively binding pathogenic bacteria

2. Bentonite-Montmorillonite Clay:

• Bentonite and montmorillonite clays exhibit high binding capacity for aflatoxins (88-95% and 74-80% respectively), ochratoxin (54-56%), and deoxynivalenol (23-73%) [citation:1]
• The layered aluminosilicate structure traps aflatoxin molecules through chemisorption, forming stable complexes that resist dissociation throughout the gastrointestinal tract [citation:1]
• Also binds ZEA, FUM, T-2, and HT-2 toxins at 25-45% levels [citation:1]

3. Enhanced Synergy from Combination:

• Research demonstrates that when glucomannan (MOS) is added to clay combinations, binding capacity increases by approximately 15-20% for ochratoxin, fumonisins, and T-2 toxin compared to clay alone [citation:1]
• The combination provides approximately 10% better adsorption of aflatoxin, 20% better for ochratoxin and fumonisins, and 5% better for T-2 toxin compared to conventional clay-based binders [citation:1]

4. Artichoke Extract (Hepatoprotective Support):

• Rich in bioactive compounds including cynarin and chlorogenic acid with antioxidant properties
• Supports liver function and bile production, enhancing the body's natural detoxification processes
• Helps mitigate oxidative stress caused by mycotoxin exposure

SPECTRUM OF ACTIVITY

QASTOX PLATINUM provides broad-spectrum protection against the major mycotoxins affecting livestock and poultry, with documented binding capacities [citation:1]:

• Aflatoxins (AF): High binding capacity (85-96%) primarily from clay components [citation:1]
• Ochratoxin A (OTA): Enhanced binding (54-56%) with superior synergy from MOS-clay combination [citation:1]
• Zearalenone (ZEA): Moderate binding (25-45%) [citation:1]
• Fumonisins (FUM): Moderate binding (25-45%) with enhanced activity from MOS addition [citation:1]
• Deoxynivalenol (DON): Moderate binding (23-73%) depending on clay composition [citation:1]
• T-2 Toxin and HT-2 Toxin: Moderate binding (25-45%) with enhanced activity from MOS addition [citation:1]

INDICATIONS

QASTOX PLATINUM is indicated for the prevention and management of mycotoxicosis in all livestock and poultry species [citation:1]. It helps mitigate the negative effects of mycotoxins including:

• Reduced feed intake and feed efficiency
• Immunosuppression leading to increased disease susceptibility
• Liver and kidney damage
• Reproductive disorders including reduced fertility, embryonic death, and abortions
• Egg production decline and poor eggshell quality in layers
• Gastrointestinal disturbances including diarrhea and malabsorption
• Milk residue transfer affecting food safety

ADVANTAGES OF YEAST-CLAY COMBINATION

Research has demonstrated that combining glucomannan (MOS) with clay minerals provides superior mycotoxin binding compared to either component alone [citation:1]:

• Enhanced broad-spectrum activity: MOS addition increases binding capacity for ochratoxin, fumonisins, and T-2 toxin by 15-20% compared to clay alone [citation:1]
• Superior aflatoxin control: Provides approximately 10% better adsorption of aflatoxins than conventional clay-based binders [citation:1]
• Selective binding: The combination effectively targets mycotoxins without significant interference with nutrient absorption [citation:1]
• Gut health promotion: MOS components act as prebiotics, supporting beneficial gut microbiota [citation:1]

DOSAGE & ADMINISTRATION

QASTOX PLATINUM is administered by mixing thoroughly into the complete feed. The dosage should be adjusted according to the level of mycotoxin contamination risk.

Standard Prevention (Low to Moderate Risk):

• Poultry (Broilers, Layers, Breeders, Turkeys): 0.5 - 1 kg per ton of feed
• Swine (Piglets, Growers, Sows): 1 - 2 kg per ton of feed
• Cattle (Dairy, Beef): 10 - 30 g per animal per day, or 1 - 2 kg per ton of concentrate feed
• Sheep & Goats: 5 - 10 g per animal per day, or 1 kg per ton of feed
• Aquaculture: 1 - 2 kg per ton of feed

High Contamination Risk (Therapeutic):

• Double the standard dosage for all species until risk subsides or clinical signs improve
• For severely contaminated feed (confirmed mycotoxin levels exceeding safe thresholds), dosages up to 3-5 kg per ton may be used under veterinary guidance

Administration Guidelines:

• Ensure uniform mixing in feed using a gradual dilution process (premix with small amount of feed before incorporating into final mix)
• For optimal results, use continuously throughout periods of mycotoxin risk, particularly during humid seasons and when using high-risk ingredients (corn, wheat, barley, soybean meal)
• In dairy cattle, can be administered in total mixed rations (TMR), concentrate mixtures, or top-dressed on feed
• Stable during feed processing including pelleting, extrusion, and expansion

BENEFITS

• Comprehensive protection: Dual-action binding addresses both polar and non-polar mycotoxins [citation:1]
• Enhanced efficacy: MOS addition increases binding capacity for OTA, FUM, and T-2 by 15-20% [citation:1]
• Liver support: Artichoke extract enhances natural detoxification processes
• Gut health promotion: MOS components act as prebiotics, supporting beneficial gut microbiota [citation:1]
• Improved feed safety: Reduces carry-over of mycotoxins into animal products (milk, eggs, meat)
• No nutrient interference: Selective binding preserves essential vitamins, minerals, and amino acids [citation:1]

CONTRAINDICATIONS & PRECAUTIONS

• Not for direct administration to animals; must be thoroughly mixed with feed
• Ensure adequate mixing to prevent segregation during transport and handling
• Do not exceed recommended dosage without veterinary consultation
• Keep out of reach of children
• Store in a cool, dry place below 30°C, protected from direct sunlight and moisture
• Use within 24 months of manufacturing date when stored properly
• Wear appropriate dust mask and gloves during handling to avoid inhalation of fine particles
• Not a substitute for good feed manufacturing practices; should be used as part of an integrated mycotoxin management program including proper crop rotation, harvest practices, and feed storage [citation:1]

STORAGE

• Store in original unopened packaging in a cool, dry place
• Keep at temperature below 30°C (86°F)
• Protect from humidity, moisture, and direct sunlight
• Close tightly after each use to prevent moisture absorption
• Do not store near chemicals, pesticides, or fertilizers

Target Species: Poultry (broilers, layers, breeders, turkeys, ducks), Swine (piglets, growers, sows), Cattle (dairy, beef), Sheep, Goats, Aquaculture, Horses, Rabbits

Pack Sizes: 25 Kg multi-layer paper bags with inner polyethylene liner

PRODUCT SUMMARY
QASTOX PLATINUM Feed Additive Powder Toxin Binder (Yeast Based) Mannan-oligosaccharides, bentonite-montmorillonite, oil and artichoke extract Livestock 25 Kg

FOR VETERINARY USE ONLY