Product Name: COLUMBA

Type: Inactivated Viral Vaccine - Emulsion for Injection

COMPOSITION

Each dose (0.3 ml) contains:

• Active Substance: Inactivated pigeon paramyxovirus type 1 (PPMV-1), strain 988M-ca
• Antigen Content: Inducing ≥ 5.8 log2 haemagglutination inhibition (HI) units in chickens
• Adjuvant: Non-mineral oil emulsion
• Excipient: Thiomersal (preservative)

DESCRIPTION

COLUMBA is an inactivated oil-adjuvanted vaccine for the active immunization of pigeons against paramyxovirosis (Newcastle disease in pigeons). The vaccine contains the inactivated pigeon paramyxovirus type 1 (PPMV-1), strain 988M-ca, which provides effective protection against this highly contagious viral disease [citation:1][citation:6].

Pigeon Paramyxovirus Type 1 (PPMV-1) is an antigenic and host variant of the Newcastle Disease Virus (NDV) that can infect pigeons of all ages and cause severe economic losses in the pigeon industry [citation:5][citation:8]. The disease is characterized by neurological signs, diarrhea, respiratory distress, and high mortality rates, particularly in young birds [citation:4].

INDICATIONS

COLUMBA is indicated for the active immunization of pigeons against paramyxovirus type 1 (PPMV-1) infection [citation:1][citation:6].

Vaccination is recommended for all pigeons, particularly those participating in competitions and exhibitions, as it is mandatory in many regions [citation:4]. The vaccine helps to:

• Reduce the severity of clinical signs associated with paramyxovirus infection [citation:9]
• Decrease mortality during outbreaks [citation:9]
• Shorten the virus excretion period after infection, reducing disease spread [citation:9]
• Provide long-lasting immunity with annual revaccination [citation:9]

DOSAGE & ADMINISTRATION

Dosage:

• 0.3 ml per pigeon, regardless of age or size [citation:3][citation:7][citation:9]
• Each vial (15 ml) contains 50 doses

Route of Administration:

• Subcutaneous injection in the back of the neck [citation:2][citation:3]
• Inject with a sterile needle (0.7 x 25 mm) inserted parallel to the cervical spine, directed toward the back [citation:4][citation:9]
• Avoid injection too close to the head or nape region [citation:4]

Preparation Before Use:

• Warm the vaccine to room temperature (approximately +22°C) before administration [citation:9]
• Shake the vial thoroughly before use [citation:9]
• Repeat shaking from time to time during the application process [citation:9]
• Use only clean, sterile syringes and needles [citation:9]

Vaccination Schedule:

• Basic Immunization (Young Pigeons): First vaccination at 3-5 weeks of age [citation:3][citation:7][citation:9]
• Second Vaccination (Booster): At 9-12 weeks of age (4 weeks after primary vaccination) [citation:3][citation:9]
• Onset of Immunity: 14 days after the last injection [citation:9]
• Duration of Immunity: 12 months after complete primary immunization [citation:9]
• Annual Revaccination: All adult pigeons should be revaccinated annually [citation:3][citation:4]
• Timing for Competitions: Revaccinate at least 3 weeks before the start of the flying or exhibition season [citation:3][citation:9]
• Breeding Timing: Revaccinate no later than 5 weeks before mating [citation:9]

CONTRAINDICATIONS & PRECAUTIONS

• Do not vaccinate unhealthy birds - only healthy pigeons should be vaccinated [citation:9]
• Avoid accidental self-injection - the oil adjuvant may cause adverse reactions in humans [citation:9]
• Do not freeze - freezing destroys the vaccine emulsion [citation:3][citation:9]
• Use within 4 hours after broaching - discard any unused vaccine after this time [citation:9]
• Keep out of reach of children [citation:9]
• Do not use after the stated expiry date [citation:9]
• Can be administered simultaneously with pigeon pox vaccine using the follicle method (separate injection sites) [citation:9]

ADVERSE REACTIONS

• A small, temporary swelling may develop at the injection site, which typically resolves within a few weeks [citation:7]
• The vaccine is formulated to cause no swelling, pain, or adverse effects when administered correctly [citation:7]
• No significant depression of spirit, appetite, or flying ability has been reported [citation:7]
• If adverse reactions occur, consult a veterinarian

WITHDRAWAL PERIOD

• Meat: Zero days - no withdrawal period required [citation:1][citation:6][citation:10]
• The vaccine does not leave harmful residues in meat products

STORAGE

• Store refrigerated at 2°C - 8°C (36°F - 46°F) [citation:3][citation:9]
• Do not freeze - freezing inactivates the vaccine [citation:3][citation:9]
• Protect from light [citation:3][citation:9]
• Store in a dry place [citation:3]
• Keep container tightly closed when not in use
• Shelf-life: 18 months from manufacturing date when stored properly [citation:3]

Target Species: Pigeons (all ages)

Pack Sizes: 15 ml glass vial (50 doses)

PRODUCT SUMMARY
COLUMBA Vaccine Inactivated Viral Vaccine Pigeon paramyxovirus 1 strain 988M-ca, inactivated, ≥5.8 log2 HI units per dose All Birds 15 ml (50 doses)

FOR VETERINARY USE ONLY