Product Name: PHARMAVAC PHA

Type: Inactivated Trivalent Viral Vaccine - Oil-Emulsion Injectable

COMPOSITION

Each dose (0.3 ml) contains:

• Active Substances:
• Inactivated Pigeon Paramyxovirus Type 1 (PPMV-1), strain 988M: ≥ 6.9 log₂ haemagglutination inhibition (HI) units
• Inactivated Pigeon Herpesvirus 1 (PHV-1), strain V298/70: ≥ 38.1 enzyme immunoassay (EU) units
• Inactivated Fowl Adenovirus Type 8 (FAdV-8), strain M2/E: ≥ 24.7 enzyme immunoassay (EU) units
• Adjuvant: Oil emulsion (paraffin oil, sorbitan oleate, polysorbate 80)
• Preservative: Thiomersal

DESCRIPTION

PHARMAVAC PHA is an inactivated trivalent oil-emulsion vaccine for the active immunization of pigeons against three major viral pathogens: paramyxovirus type 1 (PPMV-1), pigeon herpesvirus 1 (PHV-1), and fowl adenovirus type 8 (FAdV-8) .

Pigeon Paramyxovirus Type 1 (PPMV-1) is an antigenic and host variant of the Newcastle Disease Virus (NDV) that causes severe neurological signs, diarrhea, and high mortality in pigeons

Pigeon Herpesvirus 1 (PHV-1) causes respiratory distress, conjunctivitis, and immunosuppression, predisposing birds to secondary infections

Fowl Adenovirus Type 8 (FAdV-8) has been increasingly recognized as a significant pathogen in pigeons, associated with inclusion body hepatitis and other systemic diseases . This trivalent vaccine provides comprehensive protection against these three important viral diseases affecting pigeon health and performance .

INDICATIONS

PHARMAVAC PHA is indicated for the active immunization of pigeons to:

• Reduce mortality and clinical signs associated with paramyxovirus type 1 (PPMV-1) infection
• Reduce mortality, clinical signs, and virus shedding associated with pigeon herpesvirus 1 (PHV-1) infection
• Reduce clinical signs and mortality associated with fowl adenovirus type 8 (FAdV-8) infection

DOSAGE & ADMINISTRATION

Dosage:

• 0.3 ml per pigeon, regardless of age or size
• Each vial (17.5 ml) contains 50 doses

Route of Administration:

• Subcutaneous injection in the dorsal region of the neck
• Inject with a sterile needle, avoiding the head region

Preparation Before Use:

• Warm the vaccine to room temperature (approximately +22°C) before administration
• Shake the vial thoroughly before use and occasionally during administration
• Use only clean, sterile syringes and needles
• Use appropriately graduated syringes to ensure accurate dosing

Vaccination Schedule:

• Primary Vaccination: One dose from 4 weeks of age
• Booster Vaccination: A second dose is recommended 4 weeks after the primary vaccination to ensure optimal immunity
• Onset of Immunity: 3 weeks after the booster dose
• Duration of Immunity: 12 months after complete primary immunization
• Annual Revaccination: All adult pigeons should be revaccinated annually

CONTRAINDICATIONS & PRECAUTIONS

• Do not vaccinate unhealthy birds - only healthy pigeons should be vaccinated
• Avoid accidental self-injection - the oil adjuvant may cause adverse reactions in humans
• Do not freeze - freezing destroys the vaccine emulsion
• Use within 4 hours after broaching - discard any unused vaccine after this time
• Keep out of reach of children
• Do not use after the stated expiry date
• Administer under standard aseptic conditions

ADVERSE REACTIONS

• A small, temporary swelling may develop at the injection site, which typically resolves within a few weeks
• No significant depression of spirit, appetite, or flying ability has been reported
• If adverse reactions occur, consult a veterinarian

WITHDRAWAL PERIOD

• Meat: Zero days - no withdrawal period required
• The vaccine does not leave harmful residues in meat products

STORAGE

• Store refrigerated at 2°C - 8°C (36°F - 46°F)
• Do not freeze - freezing inactivates the vaccine
• Protect from light
• Store in a dry place
• Keep container tightly closed when not in use
• Shelf-life: 18 months from manufacturing date when stored properly

Target Species: Pigeons (from 4 weeks of age)

Pack Sizes: 17.5 ml glass vial (50 doses)

PRODUCT SUMMARY
PHARMAVAC PHA Vaccine Inactivated Trivalent Vaccine Inactivated pigeon paramyxovirus type 1 (PPMV-1), strain 988M ≥6.9 log₂ HI; Inactivated pigeon herpesvirus 1 (PHV-1), strain V298/70 ≥38.1 EU; Inactivated fowl adenovirus type 8 (FAdV-8), strain M2/E ≥24.7 EU per 0.3 ml dose All Birds 17.5 ml (50 doses)

FOR VETERINARY USE ONLY