A high-concentration organophosphate ectoparasiticide powder containing 98% Trichlorfon for the treatment and control of ticks, lice, mites, fleas, and fly maggots in livestock and poultry. Effective against external parasites through contact and stomach action.
Product Name: ECTOZONE-98
Type: Ectoparasiticide
COMPOSITION
Each gram contains:
- Trichlorfon USP ...... 980 mg
- Excipients ...... q.s. to 1 g
DESCRIPTION
ECTOZONE-98 is a high-concentration ectoparasiticide powder containing Trichlorfon (also known as Metrifonate), a broad-spectrum organophosphate compound with potent insecticidal, acaricidal, and larvicidal properties [citation:1]. Trichlorfon was introduced by Bayer in the 1950s and remains an effective treatment for external parasite control in livestock and poultry [citation:1][citation:5].
Mechanism of Action: Trichlorfon acts as an acetylcholinesterase (AChE) inhibitor [citation:1][citation:5][citation:8]. It binds irreversibly to the active site of the acetylcholinesterase enzyme, preventing the breakdown of acetylcholine (ACh) at nerve synapses and neuromuscular junctions [citation:1]. This leads to accumulation of acetylcholine, causing continuous nerve impulse transmission, hyperexcitation, spastic paralysis, and eventual death of the parasite [citation:1][citation:8]. The compound is non-systemic and works through both contact and stomach action against susceptible parasites [citation:5][citation:9].
Spectrum of Activity: ECTOZONE-98 is effective against a wide range of external parasites including:
- Ticks: Various species including cattle ticks (Boophilus spp.) [citation:1]
- Lice: Damalinia spp., Linognathus spp. [citation:1][citation:6]
- Mites: Various species including poultry mites (Dermanyssus gallinae) [citation:1][citation:2]
- Fleas: Ctenocephalides spp. [citation:1][citation:2]
- Flies: Horn flies (Haematobia irritans), houseflies, and fly larvae (maggots) [citation:1][citation:2]
- Warble Flies (Cattle Grubs): Hypoderma spp. [citation:1][citation:2]
INDICATIONS
ECTOZONE-98 is indicated for the treatment and control of the following ectoparasitic infestations in livestock and poultry [citation:6][citation:10]:
- Cattle, Buffalo, Sheep, Goats: Tick infestation, lice, mange mites, horn flies, and cattle grubs (warble flies) [citation:6][citation:10]
- Swine (Pigs): Lice and mange mites [citation:2][citation:7]
- Poultry: Lice, mites (including red mites), fleas, and fly control in poultry houses [citation:1][citation:2][citation:6]
- Horses: Lice and fly control; also used against horse bot flies (Gasterophilus spp.) [citation:2][citation:7]
- Humpsore: Treatment of humpsore in cattle [citation:6]
- Fish: Control of lice and external parasites in fish (certain species) [citation:6][citation:10]
DOSAGE & ADMINISTRATION
For external/topical use only. Prepare fresh solution before each application. Do not use alkaline water for dilution as it increases toxicity [citation:7][citation:10].
Recommended Dosages for External Use:
| Species | Indication | Dosage |
|---|
| Cattle, Sheep, Goats | Ticks, Lice, Mites, Flies | 2 g per liter of water (spray or dip) [citation:6] |
| Poultry | Lice, Mites, Fleas | 2 g per liter of water (spray application) [citation:6] |
| Cattle | Humpsore | 10 g per 0.5 liter water (wash affected area) or mix with vaseline for topical application [citation:6] |
| Fish | Lice of Fish | 10 g per 250 ml water per 2 decimal ponds of 3 feet depth [citation:6] or 180-450 mg per m³ water [citation:10] |
Application Guidelines:
- Spray Application: Dissolve the required amount in water and apply evenly over the entire body of the animal, ensuring thorough coverage of affected areas [citation:6].
- Dip Application: Prepare a 1500 ppm solution (1.5 g per liter) for dipping cattle, sheep, and goats [citation:2].
- Repeat Treatment: Repeat application after 21 days for complete parasite life cycle control [citation:6].
- Pour-on Application: For cattle and sheep, 2-10 mg per kg body weight can be applied as a pour-on for fly and lice control [citation:2].
WITHDRAWAL PERIODS
- Cattle, Sheep, Goats, Swine (Meat): 28 days [citation:10]
- Horses (Meat): 28 days [citation:10]
- Milk: Do not use in lactating animals producing milk for human consumption [citation:10]
- Poultry (Meat): Consult local regulations (varies by country) [citation:1]
- Eggs: Not for use in laying hens producing eggs for human consumption [citation:1]
- Fish: 500 degree days (temperature-dependent withdrawal) [citation:10]
PRECAUTIONS & CONTRAINDICATIONS
- Do not use in animals with known hypersensitivity to organophosphates [citation:10].
- Do not use in pregnant animals, especially during the last third of gestation [citation:8][citation:10].
- Do not use in debilitated, weak, or malnourished animals, or those with heart disease or gastroenteritis [citation:8][citation:10].
- Ruminants (cattle, sheep, goats) are more sensitive to trichlorfon and require careful dosing [citation:7][citation:10].
- Do not use in poultry species such as geese, ducks, and chickens (which are highly sensitive) without veterinary guidance [citation:7].
- Do not use in cats younger than 1 year [citation:8].
- Do not use in fish species such as shrimp, crab, freshwater white scorpion, and scaleless fish [citation:10].
- Do not use with alkaline drugs or alkaline water, as this can convert trichlorfon to the more toxic dichlorvos [citation:7][citation:9][citation:10].
- Do not use concurrently with other organophosphates, carbamates, levamisole, or cholinesterase inhibitors [citation:7][citation:8].
- Operator Safety: Trichlorfon is absorbed through the skin and can cause organophosphate poisoning in humans [citation:4]. Wear protective gloves, goggles, and impervious clothing when handling [citation:3][citation:4]. Avoid inhaling dust or spray mist. Wash thoroughly after use [citation:4].
- Toxic Symptoms: Overdose may cause salivation, abdominal pain, muscle tremors, miosis (constricted pupils), diarrhea, difficulty breathing, and coma [citation:8][citation:10].
- Antidote: In case of poisoning, administer atropine (0.6 mg/kg for cattle, 1.0 mg/kg for sheep, 0.1-0.3 mg/kg for horses and dogs) and pralidoxime [citation:7][citation:8].
- Environmental Precautions: Trichlorfon is toxic to aquatic organisms and dung beetles [citation:1][citation:8]. Do not contaminate water sources. Dispose of empty containers properly [citation:3][citation:10].
- Store in a cool, dry place in tightly closed containers. Protect from moisture and alkaline materials [citation:7][citation:10].
- Keep out of reach of children.
Target Species: Cattle, Sheep, Goats, Swine, Poultry, Horses, Fish (select species)
Pack Sizes: 1 Kg
PRODUCT SUMMARY
ECTOZONE-98 Powder Ectoparasiticide Each gm contains: Trichlorfon USP…………..980 mg Livestock Kg
FOR VETERINARY USE ONLY