Product Name: Impak

Type: Nutraceutical (Oral Solution / Injection)

COMPOSITION

Each ml contains:

• Vitamin E ...... 150 mg
• Sodium Selenite ...... 2 mg
• Vitamin B12 (Cyanocobalamin) ...... 0.05 mg
• Excipients ...... q.s. to 1 ml

DESCRIPTION

Impak is a nutraceutical formulation combining Vitamin E, Selenium, and Vitamin B12 for parenteral or oral administration in livestock. This synergistic combination supports antioxidant defense mechanisms, immune function, and energy metabolism in cattle, sheep, and goats .

Vitamin E and Selenium: Vitamin E and selenium work synergistically as key components of the body's antioxidant defense system . Vitamin E is a fat-soluble vitamin that acts as a chain-breaking antioxidant, protecting cell membranes from oxidative damage caused by free radicals . Selenium is an essential trace element that serves as a cofactor for glutathione peroxidase (GPx), an enzyme that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides . Together, they help maintain cellular integrity and prevent oxidative stress, which is particularly important during periods of metabolic challenge such as the transition period in dairy cows .

Vitamin B12 (Cyanocobalamin): Vitamin B12 is a water-soluble vitamin essential for normal metabolic function. It acts as a coenzyme in two critical metabolic pathways: the conversion of methylmalonyl-CoA to succinyl-CoA (involved in carbohydrate and fat metabolism) and the conversion of homocysteine to methionine (involved in protein synthesis and methylation reactions) . Vitamin B12 deficiency can lead to reduced appetite, poor growth, and impaired immune function .

Research Findings: Studies on the administration of Vitamin E and selenium combinations to transition dairy cows have demonstrated significant benefits. Research indicates that injection of Vitamin E and selenium increases serum Vitamin E concentration and total antioxidant capacity (TAC) at calving day and day 7 and 14 postpartum, increases serum selenium concentration and glutathione peroxidase activity, and increases blood neutrophil counts at calving day . Furthermore, the greatest incidence of retained placenta and mastitis was observed in control groups that did not receive supplementation, suggesting that this combination may help reduce the risk of these common transition period disorders .

INDICATIONS
Impak is indicated for the prevention and treatment of the following conditions in livestock:

• Selenium Deficiency – including white muscle disease (nutritional muscular dystrophy) in calves and lambs
• Vitamin E Deficiency – associated with reduced immune function and increased susceptibility to infections
• Transition Period Support – for dairy cows during the periparturient period (21 days prepartum to 7 days postpartum) to support antioxidant status and reduce risk of retained placenta and mastitis
• Immune Function Support – to enhance neutrophil function and overall immune competence
• Antioxidant Support – to increase total antioxidant capacity and glutathione peroxidase activity during periods of oxidative stress
• Vitamin B12 Deficiency – to address deficiency states characterized by poor appetite, reduced growth, and impaired metabolic function

DOSAGE & ADMINISTRATION

For intramuscular or subcutaneous injection, or oral administration. Use aseptic technique when administering by injection. Shake well before use. Body weight should be determined as accurately as possible to ensure proper dosage .

Recommended Dosage:

Administration Guidelines:

• Injectable Route: Administer by deep intramuscular or subcutaneous injection. For cattle, the recommended injection site is the neck region to avoid meat damage.
• Oral Route: May be administered orally as a drench for young animals or when injection is not feasible.
• Transition Period: For optimal results in dairy cows, administer on days 21 and 7 before expected calving and again at day 7 postpartum .
• Severe Deficiencies: In cases of severe selenium or vitamin E deficiency, repeat treatment may be necessary after 7-14 days.

WITHDRAWAL PERIODS

• Meat: 28 days (consult local regulations)
• Milk: 0 hours (withdrawal may vary by country; consult local regulations)

PRECAUTIONS & CONTRAINDICATIONS

• Do not exceed the recommended dosage, as selenium is toxic at high levels.
• Do not use in animals with known hypersensitivity to any component.
• Selenium Toxicity: Signs of acute selenium toxicity include salivation, muscle tremors, respiratory distress, and death. Chronic toxicity may result in hoof deformities and hair loss.
• Operator Safety: Avoid self-injection. In case of accidental injection, wash immediately and seek medical advice. Selenium compounds can be toxic to humans.
• Storage: Store in a cool, dry place below 25°C, protected from light. Do not freeze.
• Discard unused product after first opening according to local regulations.
• Keep out of reach of children.

Target Species: Cattle, Sheep, Goats

Pack Sizes: 100 ml

PRODUCT SUMMARY
Impak Oral Solution / Injection Nutraceutical Vitamin E……. 150mg Sodium Selenite…….2mg Vitamin B12 ……….0.05mg Livestock 100ml

FOR VETERINARY USE ONLY