Product Name: DINATUR

Type: Teat Sealant / Mastitis Prevention

COMPOSITION

Each 10 ml tube contains:

• Vitamin E (α-Tocopherol) ...... 10 mg
• Propylene Glycol ...... 4 ml
• Glycerol ...... 250 mg
• Purified Water ...... 5.5 ml
• Aromatic Vegetable Excipient ...... q.s. to 10 ml

DESCRIPTION

DINATUR is a non-antibiotic internal teat sealant formulated for administration at drying-off in dairy cows. It is designed to create a physical barrier within the teat canal, preventing the entry of mastitis-causing pathogens during the dry period when the natural keratin plug may be incomplete or absent [citation:8].

Mechanism of Action: The combination of propylene glycol and glycerol forms a viscous, malleable barrier that seals the teat canal. This physical plug mimics and reinforces the natural keratin plug that forms during mammary gland involution [citation:6]. Studies have shown that more than 50% of teats remain open one week after dry-off, and 23% remain open six weeks after dry-off, highlighting the importance of an artificial teat sealant in preventing new infections during this vulnerable period [citation:8].

Role of Vitamin E (α-Tocopherol): Research has demonstrated that the combination of an internal teat sealant with α-tocopherol (Vitamin E) provides significantly better preventive effects against new intramammary infections compared to sealant or antibiotic alone [citation:2][citation:4]. A study evaluating dry cow therapy reported that treatment with antibiotic + sealant + α-tocopherol (group AST) achieved the lowest new intramammary infection rate (12.5%) compared to control (47.5%), sealant alone (24.7%), and antibiotic alone (34.6%) [citation:2][citation:4].

Demulcent Properties: Glycerol and propylene glycol function as demulcents—soothing materials that protect and lubricate mucosal membranes. They help thicken, stabilize, and strengthen the protective film within the teat canal, forming a physical barrier against pathogens [citation:3].

Research on Propylene Glycol and Glycerin in Teat Sealants: Recent research on novel teat sealant formulations has evaluated mixtures based on vegetable glycerin and propylene glycol as effective carriers for antimicrobial agents. Studies have demonstrated that such mixtures can effectively deliver active ingredients and maintain their biocidal properties against mastitis pathogens including Escherichia coli and Streptococcus agalactiae [citation:1][citation:5][citation:7].

INDICATIONS
DINATUR is indicated for the following in dairy cattle:

• Prevention of New Intramammary Infections – during the dry period by providing a physical barrier in the teat canal [citation:2][citation:4][citation:8]
• Reduction of Clinical Mastitis Risk – in the postpartum period, particularly when used as part of a comprehensive dry cow management program [citation:8]
• Support for Natural Keratin Plug Formation – during mammary gland involution at drying-off [citation:6]
• Antioxidant Support – Vitamin E supplementation helps reduce oxidative stress and supports immune function in the mammary gland during the dry period [citation:2][citation:4]

DOSAGE & ADMINISTRATION

For intramammary administration only. Administer at the time of drying-off after the final milking. Use aseptic technique to prevent introduction of pathogens during administration.

Recommended Dosage:

• Dairy Cows: One 10 ml tube per teat (complete contents) at drying-off

Administration Guidelines:

• Thoroughly clean and disinfect the teat end prior to administration
• Use partial insertion technique where possible to prevent unnecessary damage to the teat orifice [citation:8]
• Full insertion may be necessary for cows with large teat orifices [citation:8]
• If the product becomes cold and difficult to administer, warm to room temperature before use [citation:8]
• Administer immediately after the final milking of the lactation
• Do not massage the teat after administration

CLINICAL EFFICACY

Research has demonstrated the efficacy of teat sealants in preventing new intramammary infections during the dry period:

• A study comparing dry cow therapy protocols found that sealant alone (group S) decreased the risk of new infections (24.7%) compared to control (47.5%) [citation:2][citation:4]
• The combination of sealant with antibiotic (group AS) achieved a new infection rate of 25% [citation:2][citation:4]
• The addition of α-tocopherol (Vitamin E) to sealant and antibiotic (group AST) showed the best preventive effect, with only 12.5% new infections [citation:2][citation:4]
• Vitamin E supplementation increased α-tocopherol levels in the mammary gland, supporting local immune function [citation:4]

WITHDRAWAL PERIODS

• Meat: Consult local regulations (non-antibiotic formulation typically requires no withdrawal)
• Milk: 0 hours after calving—the sealant is removed or expressed before the first milking [citation:8]

PRECAUTIONS & CONTRAINDICATIONS

• Do not use in lactating cows—for use at drying-off only [citation:8]
• Do not use in animals with known hypersensitivity to any component
• Do not massage the teat after administration to prevent premature expulsion of the sealant
• Post-calving Management: At freshening, the sealant should be expressed from the teat by stripping before the first milking [citation:8]
• Operator Safety: Avoid direct contact with eyes and skin. Wash hands after use.
• Storage: Store in a cool, dry place at room temperature. If stored in very cold conditions, warm syringes before use—do not immerse in water [citation:8]
• Keep out of reach of children.

Target Species: Dairy Cattle

Pack Sizes: 10 ml/tube

PRODUCT SUMMARY
DINATUR (Teat Sealant) Liquid tube Vitamin E …………… 10 mg Propylene glycol……… 4 ml Glycerol ………………… 250 mg Purified water…………… 5.5 ml Aromatic vegetable excipient to 10 ml Livestock 10ml/tube

FOR VETERINARY USE ONLY