Product Name: Josazone

COMPOSITION
Each 100 gm contains:

• Josamycin ..... 18 gm

INDICATION
Josazone is a macrolide antibiotic which is effective in vitro against Mycoplasma and Gram-positive Cocci (Staphylococcus, Streptococcus, and Diplococcus). Josazone is used for infections with certain bacteria that are sensitive to its active ingredient. It is indicated for the treatment of:

• Chronic Respiratory Diseases (CRD)
• Sinusitis
• Synovitis
• Arthritis caused by Mycoplasma and Gram-positive cocci in chickens
• Pneumonia
• Stimulation of the immunological system after vaccination, weaning, or transportation

MECHANISM OF ACTION
As a protein synthesis inhibitor, Josazone works by:

• Preventing the transfer of the peptide tRNA from the A-site to the P-site
• Promoting peptidyl tRNA dissociation
• Blocking Peptidyl Transferase
• Preventing Ribosomal Assembly

It binds to the 50S ribosomal subunit, inhibiting polypeptide chain elongation and protein synthesis, resulting in the inhibition of growth and multiplication of bacteria.

DOSAGE

For Treatment:

• Administer 2 grams per 5 liters of drinking water
• OR 100 grams per 200 kg body weight
• Continue for 5 days

For Prevention:

• Administer 1/2 of the treatment dose

WITHDRAWAL TIME: None

CONTRAINDICATION:
Do not use in animals hypersensitive to any components.

PRESERVATION

• Store in a cool place
• Keep out of direct sunlight

FOR VETERINARY USE ONLY