Product Name: SCOUR ZONE

Type: Oral Liquid Suspension - Antidiarrheal Antibiotic Combination

COMPOSITION

Each ml contains:

• Sulphadiazine BP ...... 35.500 mg
• Sulphadimidine (BP Vet) ...... 28.400 mg
• Neomycin Sulphate BP ...... 1.800 mg
• Kaolin (BP) ...... 103.300 mg
• Pectin USP ...... 7.100 mg
• Hyoscine methyl bromide (Eu) ...... 0.040 mg
• Vitamin B1 BP ...... 0.150 mg
• Vitamin B2 (BP) ...... 0.200 mg

DESCRIPTION

SCOUR ZONE is a comprehensive, broad-spectrum oral suspension specifically formulated for the treatment and management of gastrointestinal infections (scours) in poultry and livestock. This multi-action formulation combines systemic and locally acting antibacterials with adsorbents, antispasmodics, and vitamins to address both the infectious causes of diarrhea and its clinical consequences .

Scours (neonatal diarrhea) in young animals can be caused by a variety of bacterial pathogens including E. coli, Salmonella spp., and other enteropathogens, leading to significant morbidity, mortality, and economic losses. SCOUR ZONE is designed to provide comprehensive therapy by combining multiple mechanisms of action .

MECHANISM OF ACTION

Antibacterial Components:

• Sulphadiazine and Sulphadimidine: These systemic sulfonamides inhibit bacterial folate synthesis by competitively blocking para-aminobenzoic acid (PABA), disrupting nucleic acid production. They provide broad-spectrum activity against gram-positive and gram-negative bacteria including E. coli, Salmonella, Pasteurella, and Streptococcus species
• Neomycin Sulphate: A locally acting aminoglycoside antibiotic that is poorly absorbed from the gastrointestinal tract. It exerts its bactericidal effect by binding to the 30S ribosomal subunit, inhibiting protein synthesis. It is particularly effective against E. coli and other enteric pathogens in the gut lumen

Adsorbent and Protective Components:

• Kaolin: A naturally occurring aluminum silicate that acts as an adsorbent, binding to bacterial toxins and irritants in the gastrointestinal tract, facilitating their elimination in feces . It also provides a protective coating to inflamed intestinal mucosa
• Pectin: A soluble fiber that absorbs water, helps firm stools, and provides a soothing, protective coating to the intestinal lining

Antispasmodic Component:

• Hyoscine methyl bromide: An anticholinergic agent that reduces intestinal smooth muscle spasm and motility, decreasing abdominal pain and cramping associated with enteritis . It helps slow transit time, allowing for better absorption of nutrients and fluids .

Vitamin Support:

• Vitamin B1 (Thiamine) and Vitamin B2 (Riboflavin): Essential B vitamins that may be depleted during diarrhea due to malabsorption and increased metabolic demand. They support energy metabolism, nerve function, and recovery .

INDICATIONS

SCOUR ZONE is indicated for the prevention and treatment of gastrointestinal infections and associated diarrhea in poultry and livestock .

Target Pathogens:

• Escherichia coli - neonatal colibacillosis, enteritis
• Salmonella spp. - salmonellosis, paratyphoid infections
• Pasteurella spp.
• Streptococcus spp. and Staphylococcus spp.
• Clostridium spp. - enterotoxemia (partial activity)

Disease Conditions:

• Neonatal diarrhea (scours) of bacterial origin in poultry and young livestock
• Enteritis and enterotoxemia caused by E. coli, Salmonella spp., and other enteropathogens
• Scour/pneumonia complex in young livestock
• Bacterial gastroenteritis in poultry, calves, lambs, kids, piglets, and other species
• Secondary bacterial enteritis following viral or parasitic infections

PHARMACOKINETIC PROPERTIES

• Sulfonamides: Rapidly absorbed from the gastrointestinal tract, widely distributed throughout body tissues. Achieve therapeutic concentrations in blood and tissues within 2-4 hours. Excreted primarily in urine.
• Neomycin: Poorly absorbed from the gastrointestinal tract (<3%), exerting its primary bactericidal effect in the gut lumen. Excreted almost completely in feces.
• Kaolin and Pectin: Not absorbed; act locally within the intestinal tract and are eliminated in feces.
• Hyoscine: Partially absorbed; acts both locally and systemically to reduce intestinal motility.

DOSAGE & ADMINISTRATION

SCOUR ZONE is administered orally. SHAKE WELL BEFORE USE. For optimal results, administer as soon as signs of diarrhea appear.

Recommended Dosage:

• Initial Dose: 1-2 ml per kg body weight (first administration)
• Maintenance Dose: 0.5-1 ml per kg body weight, administered twice daily (morning and evening)
• Treatment Duration: 3-5 consecutive days or for 24 hours after symptoms resolve. For salmonellosis and bacterial pneumonia, continue for at least 5 days .

Species-Specific Dosing Guidelines:

• Poultry (Chickens, Turkeys, Ducks): 0.5-1 ml per liter of drinking water, or individual dosing as above for 3-5 days
• Calves, Foals: 20-40 ml per animal twice daily for 3-5 days
• Lambs, Kids: 5-10 ml per animal twice daily for 3-5 days
• Piglets: 2-5 ml per animal twice daily for 3-5 days

Administration Guidelines:

• Shake the bottle thoroughly before each use to ensure uniform suspension of ingredients
• For individual treatment, administer directly into the mouth using a dosing syringe
• For flock/herd treatment, administer via drinking water; ensure all animals have adequate access
• Provide fresh, clean water in addition to medicated water
• In cases of severe dehydration, consider additional fluid and electrolyte therapy
• If symptoms persist beyond 3-4 days, consult a veterinarian

EFFICACY DATA

Combination Therapy in Salmonella Infections:

• Research has demonstrated that combination therapy with antimicrobial agents (including sulfadiazine/trimethoprim) followed by restoration of normal intestinal microflora can effectively reduce Salmonella infection rates in chickens .
• Studies show that when only antimicrobials are given, salmonellae may rapidly reappear in the intestines when therapy is stopped, highlighting the importance of comprehensive gut health support .
• The inclusion of adsorbents like kaolin and pectin helps remove bacterial toxins and protect the intestinal lining, supporting recovery .

Role of Kaolin and Pectin:

• Kaolin and pectin are well-established adsorbents that bind bacterial toxins and provide a protective coating to inflamed intestinal mucosa
• These components are particularly useful as supportive therapy in infectious diarrhea, helping to reduce fluid loss and promote recovery

CONTRAINDICATIONS & PRECAUTIONS

• Hypersensitivity: Do not use in animals with known hypersensitivity to sulfonamides, aminoglycosides (neomycin), or hyoscine
• Organ dysfunction: Do not administer to animals with impaired kidney or liver function
• Ruminants: Use with caution in ruminating adult livestock, as kaolin and pectin may interfere with rumen fermentation and nutrient absorption
• Lactating animals: Not for use in lactating dairy cows producing milk for human consumption
• Egg production: Not for use in laying hens producing eggs for human consumption
• Drug interactions: Do not use in animals receiving folic acid antagonists (e.g., methotrexate) due to possible drug interactions with sulfonamides
• Keep out of reach of children
• Store in a cool, dry place below 30°C, protected from direct sunlight
• Protect from freezing
• Shake well before each use
• Use within 28 days after first opening

ADVERSE REACTIONS

• Sulfonamides may rarely cause crystalluria; ensure adequate water intake during treatment
• Hypersensitivity reactions may occur in susceptible animals
• No undesirable effects are expected when the prescribed dosage regimen is followed
• If adverse reactions occur, discontinue use and consult a veterinarian

WITHDRAWAL PERIOD

• Meat (Poultry, Cattle, Sheep, Goats, Swine): 14 days
• Milk: Not for use in lactating dairy cows producing milk for human consumption
• Eggs: Not for use in laying hens producing eggs for human consumption
• Note: Withdrawal periods may vary by country; always follow local regulatory requirements

STORAGE

• Store in a cool, dry place below 30°C
• Protect from direct sunlight and freezing
• Keep container tightly closed when not in use
• Do not freeze
• If crystallization occurs at low temperatures, warm gently and shake to redissolve before use

Target Species: Poultry (Broilers, Layers, Breeders, Turkeys, Ducks, Geese), Calves, Lambs, Kids, Piglets, Foals

Pack Sizes: 1 Liter HDPE bottle

PRODUCT SUMMARY
SCOUR ZONE Liquid Antibiotic Sulphadiazine 35.500mg, Neomycin sulphate 1.800mg, Pectin 7.100mg, Vitamin B1 0.150mg, Sulphadimidine 28.400mg, Hyoscine methyl bromide 0.040mg, Kaolin 103.300mg, Vitamin B2 0.200mg per ml Poultry 1 Liter

FOR VETERINARY USE ONLY