Product Name: SPECTIN-100

Type: Oral Water-Soluble Powder - Antibiotic Combination

COMPOSITION

Each gram contains:

• Lincomycin Hydrochloride USP ...... 33.3 mg
• Spectinomycin Sulfate BP ...... 66.7 mg

DESCRIPTION

SPECTIN-100 is a broad-spectrum antibiotic combination powder containing lincomycin (a lincosamide antibiotic) and spectinomycin (an aminocyclitol antibiotic). This synergistic combination provides enhanced antibacterial activity against both gram-positive and gram-negative pathogens, as well as Mycoplasma species, making it an essential tool for controlling respiratory diseases in poultry

Lincomycin is a lincosamide antibiotic produced by Streptomyces lincolnensis that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, interfering with peptidyl transferase activity. Spectinomycin is an aminocyclitol antibiotic that binds to the 30S ribosomal subunit, blocking bacterial protein production. The combination delivers a powerful synergistic effect that halts bacterial growth and eradicates infections quickly and effectively

MECHANISM OF ACTION

Lincomycin:

• Inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit
• Interferes with the peptidyl transferase reaction, preventing peptide bond formation
• Active against gram-positive bacteria, anaerobic bacteria, and Mycoplasma species

Spectinomycin:

• Binds to the 30S ribosomal subunit, blocking bacterial protein production
• Interferes with the initiation of protein synthesis and causes misreading of mRNA
• Particularly effective against gram-negative bacteria and Mycoplasma species

Synergistic Combination:

• Combined with lincomycin, the antimicrobial activity against Mycoplasma may increase significantly and expand the antibacterial spectrum
• The dual ribosomal binding sites (50S and 30S) provide enhanced bactericidal activity
• This combination is particularly effective against simultaneous infections caused by Mycoplasma gallisepticum and avian pathogenic E. coli (APEC)

ANTIMICROBIAL SPECTRUM

SPECTIN-100 is effective against a broad range of microorganisms:

Mycoplasma:

• Mycoplasma gallisepticum - chronic respiratory disease (CRD)
• Mycoplasma synoviae - infectious synovitis, respiratory disease
• Mycoplasma meleagridis - in turkeys

Gram-Positive Bacteria:

• Staphylococcus spp.
• Streptococcus spp.
• Clostridium perfringens

Gram-Negative Bacteria:

• Escherichia coli - colibacillosis
• Salmonella spp. - salmonellosis
• Pasteurella multocida - fowl cholera
• Haemophilus paragallinarum - infectious coryza

INDICATIONS

SPECTIN-100 is indicated for the control and treatment of infections caused by lincomycin and spectinomycin-sensitive bacteria in poultry

Poultry (Chickens):

• Control of Airsacculitis caused by either Mycoplasma synoviae or Mycoplasma gallisepticum susceptible to lincomycin-spectinomycin
• Complicated Chronic Respiratory Disease (Air Sac Infection) caused by Escherichia coli and M. gallisepticum susceptible to lincomycin-spectinomycin
• Treatment of Chronic Respiratory Disease (CRD) associated with mycoplasmal and coliform infections in growing chickens
• Prevention of CRD during the first days of life and during stress periods

Disease Conditions:

• Chronic Respiratory Disease (CRD) - respiratory distress, nasal discharge, coughing
• Airsacculitis - inflammation of air sacs, often complicated by E. coli
• Infectious Synovitis - caused by Mycoplasma synoviae
• Secondary bacterial infections associated with viral diseases

PHARMACOKINETIC PROPERTIES

• Lincomycin: Rapidly absorbed after oral administration in broiler chickens. Following oral administration at 10 mg/kg body weight, lincomycin shows a good pharmacokinetic profile with a long elimination half-life (t½β) of 7.041 ± 0.402 hours
• Spectinomycin: Rapidly absorbed but also rapidly eliminated; achieves therapeutic concentrations in respiratory tissues
• Distribution: Both antibiotics are widely distributed throughout the body, achieving therapeutic concentrations in respiratory tract tissues
• Elimination: Excreted primarily in urine and bile

DOSAGE & ADMINISTRATION

SPECTIN-100 is administered via drinking water. For optimal results, fresh medicated water should be prepared daily.

Recommended Dosage:

• Poultry (Broilers, Layers, Breeders): 1 g per 2-4 liters of drinking water (based on 1:2 ratio of lincomycin:spectinomycin)
• Alternative Dosage: Provide 2 grams (g) antibiotic activity per gallon of drinking water (approximately 0.53 g per liter)
• Treatment Duration: 3-7 consecutive days. For prevention of CRD, administer for the first 3-5 days of life and again for 1-2 days at approximately 4 weeks of age
• Prevention: Administer at the above dosage for the first 3 to 5 days of life and again for one or two days at about 4 weeks of age. The longer period (5 days) of initial administration is recommended if disease has been a problem in the past on the premises

Administration Guidelines:

• Calculate total daily water consumption based on flock size, age, and environmental temperature
• Dissolve the required amount of SPECTIN-100 in a small volume of water, then add to the main drinking water tank
• For use in automatic water proportioners, prepare stock solution according to manufacturer specifications
• Prepare fresh medicated water daily; discard any unused solution after 24 hours
• Ensure medicated water is the sole source of drinking water during treatment
• For best results, administer over 4-8 hours; may withhold water for 1-2 hours before treatment to encourage rapid consumption
• For use in chickens up to 7 days of age: administer as the sole source of water for the first 5 to 7 days of life

EFFICACY AND SYNERGY DATA

Synergistic Activity:

• Combined with lincomycin, the antimicrobial activity against Mycoplasma may increase significantly and expand the antibacterial spectrum
• In vitro studies confirm that the combination is effective against Mycoplasma gallisepticum and avian pathogenic E. coli (APEC)
• The dual ribosomal binding sites (50S and 30S) provide enhanced bactericidal activity

Pharmacokinetic Studies:

• Following oral administration of lincomycin at 10 mg/kg body weight in broiler chickens, the drug shows a good pharmacokinetic profile with a long elimination half-life (t½β) of 7.041 ± 0.402 hours
• This prolonged half-life supports once-daily or continuous dosing regimens

DRUG INTERACTIONS

• Antagonistic: There is antagonism when combined with erythromycin and other macrolide antibiotics
• Interactions: The effect of anticholinesterase drugs may be reduced when combined with lincomycin
• Synergistic: The combination of lincomycin and spectinomycin itself is synergistic; no other significant synergistic interactions documented

CONTRAINDICATIONS & PRECAUTIONS

• Egg production: Do not use in laying hens producing eggs for human consumption. This product must not be used in laying birds
• Young birds: For use in chickens only; some formulations restrict use to chickens up to 7 days of age
• Sensitive species: Do not allow rabbits, hamsters, guinea pigs, horses, dairy cattle, or other ruminants access to feeds and/or drinking water containing lincomycin. Ingestion by these species may result in severe gastrointestinal effects or metabolic disorders (i.e., ketosis in dairy cattle)
• Hypersensitivity: Do not use in animals with known hypersensitivity to lincosamides or spectinomycin
• Renal dysfunction: Use with caution in animals with impaired renal function
• Keep out of reach of children
• When handling the product, avoid inhalation, oral exposure, and direct contact with skin or eyes
• Store in a dry place between 15-30°C (59-86°F)
• Protect from direct sunlight and moisture
• Use within 28 days after first opening

ADVERSE REACTIONS

• At recommended doses, the combination is generally well tolerated in poultry
• No adverse reactions are observed at recommended dose
• If adverse reactions occur, discontinue use and consult a veterinarian

WITHDRAWAL PERIOD

• Meat (Poultry): 5 days (according to EU and other regulatory standards)
• Alternative Withdrawal: 72 hours (3 days) for chickens according to Canadian and other regulatory standards
• Eggs: Not for use in laying hens producing eggs for human consumption
• Note: Withdrawal periods may vary by country; always follow local regulatory requirements. For Canada: 72 hours; for EU: 5 days

STORAGE

• Store in a cool, dry place below 30°C
• Protect from direct sunlight and moisture
• Keep container tightly closed when not in use
• Do not freeze

Target Species: Poultry (Chickens, Turkeys, Ducks, Geese, Quail) - Primarily for growing chickens

Pack Sizes: 1 Kg HDPE container

PRODUCT SUMMARY
SPECTIN-100 Powder Antibiotic Lincomycin HCl USP 33.3mg, Spectinomycin Sulphate BP 66.7mg per gram Poultry 1 Kg

FOR VETERINARY USE ONLY